Genotype-phenotype distinction
The
genotype-phenotype distinction refers to the fact that while
genotype and
phenotype of an
organism are related, they do not necessarily coincide. The
genotype of an organism represents its exact
genetic makeup, that is, the particular set of
genes it possesses. Two organisms whose genes differ at even one
locus (position in their
genome) are said to have different genotypes. The term "genotype" refers, then, to the full
hereditary information of an organism. The
phenotype of an organism, on the other hand, represents its actual physical properties, such as height, weight, hair color, and so on. The
mapping of a set of genotypes to a set of phenotypes is sometimes referred to as the
genotype-phenotype map.
An organism's genotype is the largest influencing factor in the development of its phenotype, but it is not the only one. Even two organisms with identical genotypes normally differ in their phenotypes. One experiences this in everyday life with
monozygous (i.e. identical) twins. Identical twins share the same genotype, since their genomes are identical; but they never have the same phenotype, although their phenotypes may be very similar. This is apparent in the fact that their mothers and close friends can always tell them apart, even though others might not be able to see the subtle differences. Further, identical twins can be distinguished by their
fingerprints, which are never completely identical.
The concept of
phenotypic plasticity describes the degree to which an organism's phenotype is determined by its genotype. A high level of plasticity means that
environmental factors have a strong influence on the particular phenotype that develops. If there is little plasticity, the phenotype of an organism can be reliably predicted from knowledge of the genotype, regardless of
environmental peculiarities during development. An example of high plasticity can be observed in
larval
newts
1 when these larvae sense the presence of
predators such as
dragonflies, they develop larger heads and tails relative to their body size and display darker
pigmentation. Larvae with these traits have a higher chance of
survival when exposed to the predators, but grow more slowly than other phenotypes.
In contrast to phenotypic plasticity, the concept of
genetic canalization addresses the extent to which an organism's phenotype allows conclusions about its genotype. A phenotype is said to be canalized if
mutations (changes in the genome) do not noticeably affect the physical properties of the organism. This means that a canalized phenotype may form from a large variety of different genotypes, in which case it is not possible to exactly predict the genotype from knowledge of the phenotype. If canalization is not present, small changes in the genome have an immediate effect on the phenotype that develops.
#J. Van Buskirk and B. R. Schmidt, "Predator-induced Phenotypic Plasticity in Larval Newts: Trade-offs, Selection, and Variation in Nature,"
Ecology 81 (2000): 3009-3028.
*
Stanford Encyclopedia of Philosophy entryAn earlier version of this article was posted on Nupedia.
