Old Main

Old Main can refer to:
* Old Main (University of Arkansas), the first building built on the campus of the University of Arkansas in Fayetteville, Arkansas.
* Old Main (Pennsylvania State University), a building on the campus of Pennsylvania State University.
* Old Main (Mississippi State University), historic dormitory on the campus of Mississippi State University destroyed by fire in 1959.
*Old Main (Arizona State University), the first building on the campus of Arizona State University in Tempe, Arizona.
*Old Main (Wayne State University), a historical building on the campus of Wayne State University, which originally housed the Detroit Central High School.