Expert: Dr Ian Jackson - please note UK based - 12/6/2008

Question
Hello,

Recently I discovered my aunt on my dad's side (who is only his half sister-same mother not father) experienced an episode of malignant hyperthermia during breast surgery.  I am scheduled to have surgery soon to have my meniscus repaired and some free floating chips removed in my knee.  I have had multiple surgeries previously with no problems, but I know the pre-op people expressed some concern regarding it.  What I am curious is what is the potential of developing a problem at age 28 after having multiple uneventful surgeries, and would you consider it an increased risk and if so, what can or will be done to minimize those risks?  Thank you for your information.

Answer
Amanda
You have a somewhat tenuous link genetically with your aunt but even so there is a slightly increased risk that you may be MH susceptible. It is quite possible for someone who is susceptable to have several uneventful anaesthetics before running into problems. However it is also fairly easy to avoid the trigger agents. Your case should be discussed with the centre who is testing your aunt (and presumably her blood relatives) to check to see if you need a special diagnostic test or not to rule out MH susceptibility.
Kind regards
Dr Ian Jackson