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Question
Dog weighed 14.5 kg.  Prescribed corvental 100mg tablet 3 times daily.  Was given theophylline 400mg tablets 3 times daily for 3 days and on the 4th day received 4 tablets.  Overdosed. How would this have affected his bloods and what adverse effects would it have caused.  He had lymphoma stage 3/4 diagnosed by another vet.  I had to put him to sleep.  Had hoped to try chemotherapy but he was suffering to much.  Would appreciate a detailed answer if possible.  Thank youl

Answer
Hi,

Theophylline is a bronchodilator that relax the large air passages in the lungs and make breathing easier.It is a prescription medication that’s used to treat asthmatic bronchitis, chronic obstructive pulmonary disease and congestive heart failure in dogs. It is  used to reduce inflammation and swelling of muscles in the lungs and chest. It facilitates respiration by widening bronchial tubes and relaxing muscles.For dogs, theophylline is dosed at 3 to 5 mg per pound (6 to 10 mg/kg) three times daily, higher doses may be prescribed with the twice-daily extended action preparations.
An overdose of theophylline may cause slow heart rate, abnormal heart rate, seizures, circulatory system failure, and death.

The life expectancy of  untreated dogs with generalized lymphoma (Stage III, IV, or V) averages 4 to 6 weeks. Oral prednisone therapy may reduce the swellings and discomfort, but probably will not appreciably extend their life span. It must also be noted that oral prednisone treatment prior to chemotherapy is not recommended and may actually reduce the effectiveness of the chemotherapy.

In dogs that do undergo one of the recommended chemotherapy protocols, life expectancy can extend out to a year and occasionally longer. However, even dogs that receive appropriate chemotherapy usually do not live longer than a year. If a dog tolerates chemotherapy (most dogs do) their quality of life can be quite good during the treatment period.  

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Dr S Bindu Anand

Expertise

Large and Small Animal Medicine and Surgery, Farm Management,Preventive medicine http://binduanand.webs.com/

Experience

A Senior Veterinary Surgeon with more than 25 years’ experience in the field of Veterinary Science and Animal Husbandry. Mixed animal Practice that will utilize my skills in medicine and surgery, public health, client relations, and developing relationships within the community, such as humane society

Organizations
Veterinary Consultant with Department of Animal Resources,Ministry of Environment,State of Qatar (Present). Animal Husbandry Department, Government of Kerala, India. Oakland's Park, Gloucestershire, United Kingdom. Severnside Veterinary Center, Gloucestershire, United Kingdom. Saud Bahwan Group, Sultanate of Oman. Trivandrum Regional Co-operative Milk Producers Union,Kerala,India.

Education/Credentials
BVSc & AH (Bachelor of Veterinary Science and Animal Husbandry) 1990. College of Veterinary & Animal Sciences, Mannuthy, Thrissur, Kerala, India under Kerala Agricultural University. Certificates Of Accomplishments- Equine Nutrition- University of Edinburgh Principles of Public Health-University of California, Irvine. AIDS- Emory University, Atlanta, Georgia. General Environmental Health – EPHOC-Tulane University School of Public Health and Tropical Medicine and the University of Alabama at Birmingham School of Public Health. Food Protection-EPHOC-Tulane University School of Public Health and Tropical Medicine and the University of Alabama at Birmingham School of Public Health. Zoonoses:University of Minnesota-School of Public Health online. Food Safety:University of Minnesota-School of Public Health online. Occupational Safety and Health-EPHOC-Tulane University School of Public Health and Tropical Medicine and the University of Alabama at Birmingham School of Public Health. Rabies Educator Certified -Global Alliance for Rabies Control. Animal Handler & Vaccinator Educator Certified -Global Alliance for Rabies Control. Wildlife Conservation-United for Wildlife

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