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Sorry if this question is off topic, its something my friends and I have been wondering for some time and you seem an approiate source. Our friend is 310 pounds, he says he has a low tolernance for beer and 2 gets him buzzed. Physically this isnt possible, do you agree?

Answer
A normal low tolerance,for alcohol,stems from never having consumed alcohol.I.E.flushing of the face,sick to the stomach Cigarette smokers,when first starting,also experience low tolerance,I.E.dizzyness.As the body builds tolerance,these symptoms diminish.There are people that have no tolerance at all,for alcohol.It's genetic,and normally Asian people are affected.Men have more tolerance for alcohol,then women,because of the amount of body water.The friend,you are  speaking of,could be an exception,but highly unlikely

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John Snyder

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I will answer questions about the brewing of beer,it`s process flow,quality control,and raw materials used in the brewing process.Brewing calculations, recipe formulations,and solving of brewing,fermenting, storage and finishing problems,will also be answered

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41 years in the beer industry,with 20 years as Brewmaster;10 years as brewing Chemist

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B.S.in chemistry.Brewmasters degree.Sensory training

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