Biology/genetics
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Question
what is the role of non template strand in transcription?does it helps RNA polymerase in reading?
The nontemplate strand, of course, is not transcribed during transcription and has no role in the actual elongation process. It appears that the nontemplate strand does have a role in controlling the initiation of transcription, as seen here:
http://www.jbc.org/cgi/content/abstract/280/5/3474
In the experiment, it was found that interactions of the template strand with the nontemplate strand forced the completion of abortive transcripts that were not able go on to become full RNA transcripts. The role of the non-template strand seems to be in the ending of abortive transcripts early in the transcription process. RNA polymerase does not read the non-template strand when editing; it stops at mismatched base pairs and corrects them as it proceeds along the template strand.
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John Locke
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I will answer all biology-related questions through the undergraduate level. I will explain unclear concepts and suggest approaches to solving problems, but would prefer not to completely solve homework problems for you. If you are completely stumped on homework, tell me what you already know and I will help you as much as possible. Please do not ask me for ideas on school research projects; part of research is determining a suitable area of investigation, and that's not a task that should be completed by someone else. Please don't simply send me your homework for solutions. If you are having difficulty after you have started an analysis, I will be happy to direct your thinking; in particular, I would prefer to not simply solve pedigrees for students, but I will be happy to assist in solving pedigrees that you have already started. If you don't understand how to analyze a pedigree, I'd highly recommend watching this video, in which a biology professor explains the basic concepts of pedigree analysis: http://www.youtube.com/watch?v=HbIHjsn5cHo
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I have a BS in Bioengineering with a concentration in Chemical Engineering (which included a heavy focus on biology), and have taught biology, biochemistry, and related subjects for some time now.
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BS Bioengineering, Penn State University
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