Biology/Genetic basis for Dandy Walker Syndrome
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Question
Hi Dana,
I have recently found out that I am pregnant with my first child. I have two younger brothers, one has dandy walker syndrome and one does not. Can you tell me whether this syndrome is hereditary or not?
Dear Nikita,
While Dandy-Walker Syndrome is congenital, its genetics are complex and not yet fully understood. at this time, the disorder has been linked to problems on several different chromosomes:
http://www.associatedcontent.com/article/628543/dandywalker_syndrome_linked_to_c
though it can occur without apparent genetic component, possibly due to pre-natal exposure to teratogens that mimic the effects of mutations at the chromosomal locations.
So the short answer is: we don't really know the genetic component of DWS yet. Since you have a sibling with DWS, it might be wise to consult with a genetic counselor. But the fact that you do not have signs of the disease suggests that your child will likely be normal, especially if the father has no family history of DWS.
I hope this helps.
Dana
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Answers by Expert:
Dana Krempels, Ph.D.
Expertise
I can answer biology-related questions in the areas of evolution, zoology, botany, genetics, and ecology. But I don't answer homework questions or provide ideas for your science fair projects. So students please do your learning the right way by reading your text assignments and studying!
Experience
At the University of Miami, I teach Evolution and Biodiversity, Botany, Zoology, Genetics, Ecology, and a variety of seminars (e.g., the Biology and Evolution of Human Gender Roles).
Education/Credentials
I have a B.S. in Biology and an A.B. in English from the University of Southern California (1980).
I earned my Ph.D. in Biology in the area of evolutionary biology/visual physiology from the University of Miami in 1989.
Past/Present Clients
I am currently an "expert" in both the "Rabbits" and "Wild Animals" categories.
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