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Question
Dear Christen,

http://en.wikipedia.org/wiki/Black_bile mentions “black bile”. Although the theory of the humours has long been refuted, presumable “black bile” does refer to some kind of bodily secretion – which one or ones might it be, please?

All the best,

Simon

Answer
I'll take a shot at this, Simon. While I cannot offer an exact answer (there is no indication that "black bile" referred to a specific, known bodily fluid while the humoral theory was in vogue), the excess of black bile was supposed to be associated with melancholia. The condition that resembles melancholia most closely is clinical depression; presumably, you could associate an excess of black bile with the bodily substances that, in excess, cause depression. No such substances exist exactly, though long-term excesses of stress hormones (like corticoid hormones, adrenaline, corticotropin, etc.) often result from depression. Make of that what you will--humoral theory, as you know, persisted for a long time with no evidence of efficacy.

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