Biology/How will the drug affect urine formation?
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Question
A drug inhibits the formation of ATP by the cells of the proximal tubule is introduced into the nephron. How will the drug affect urine formation? Provide a complete physiological explanation.
Marius, I cannot provide a complete physiological explanation, but let me give you some considerations for how to answer this:
1. What is ATP used for in the proximal tubule?
2. What direction of flow (for water, ions, glucose, etc.) is achieved by the use of ATP in the PT?
3. What would happen without the presence of ATP?
4. How would this affect the downstream presence of ions, water, glucose, etc.?
5. Given your above answers, how would the flow of water into the tubules be affected? Would this tend to increase or decrease urine output?
Here's a website that discusses the basic physiology and anatomy, along with cross-sections:
http://trc.ucdavis.edu/mjguinan/apc100/modules/Urinary/mammal/cortex1/cortex.htm...
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John Locke
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I will answer all biology-related questions through the undergraduate level. I will explain unclear concepts and suggest approaches to solving problems, but would prefer not to completely solve homework problems for you. If you are completely stumped on homework, tell me what you already know and I will help you as much as possible. Please do not ask me for ideas on school research projects; part of research is determining a suitable area of investigation, and that's not a task that should be completed by someone else. Please don't simply send me your homework for solutions. If you are having difficulty after you have started an analysis, I will be happy to direct your thinking; in particular, I would prefer to not simply solve pedigrees for students, but I will be happy to assist in solving pedigrees that you have already started. If you don't understand how to analyze a pedigree, I'd highly recommend watching this video, in which a biology professor explains the basic concepts of pedigree analysis: http://www.youtube.com/watch?v=HbIHjsn5cHo
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I have a BS in Bioengineering with a concentration in Chemical Engineering (which included a heavy focus on biology), and have taught biology, biochemistry, and related subjects for some time now.
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BS Bioengineering, Penn State University
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