Biotech & Biomedical/blood brain barrier

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Expert: - 10/10/2008


Question
Hello Sir!
  i need your help in making a list of drugs that can cross blood brain barrier,i only have a few to name but couldn't find a whole list of drugs currently in medical use.

Answer
Hi, Sabiya,

Thanks for your question.

Relatively easy - any drug that is designed to be given orally, i.m. s.c. or i.v. and acts on the brain MUST cross the blood-brain barrier.

e.g. opiates (morphine, methadone, meperidine), anxiolytics (diazepam, temazepam), SSRI's (paroxetine), anti-psychotics (chlorpromazine, promethazine).

Drug needs to be lipid (fat) soluble to cross the BBB.

OK?

Paul  

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Dr.Paul Skett

Expertise

drug metabolism or biotransformation from basic to advanced, hepatocytes from basic to advanced, drug toxicity and side effects, alcohol clearance and levels

Experience

32 years research experience in above areas, 30 years educational experience in University. Retained expert for numerous legal firms dealing with matters of drugs (legal and illegal)and alcohol.

Education/Credentials
B.Sc(Hons) Biochemistry, University of Liverpool, UK
fil.dr. (Medical Chemistry) Karolinska Institute, Stockholm, Sweden

Fellow of the British Pharmacological Society

Fellow of the Higher Education Academy

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