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Biotech & Biomedical/Theophylline half life
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Question
Why is the half life of theophylline shorter in young children than adults?
Hi, Clare,
Thanks for your question.
Two main reasons:
1. The enzyme that clears theophylline (cytochrome P-450 1A2) is higher in children than in adults - it also increases in smokers.
2. Protein binding of theophylline in blood is lower in children than in adults - thus more free theophylline to be cleared.
Hope this helps.
Best wishes,
Paul
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Biotech & Biomedical
Answers by Expert:
Dr.Paul Skett
Expertise
drug metabolism or biotransformation from basic to advanced, hepatocytes from basic to advanced, drug toxicity and side effects, alcohol clearance and levels
Experience
32 years research experience in above areas, 30 years educational experience in University. Retained expert for numerous legal firms dealing with matters of drugs (legal and illegal)and alcohol.
Education/Credentials
B.Sc(Hons) Biochemistry, University of Liverpool, UK
fil.dr. (Medical Chemistry) Karolinska Institute, Stockholm, Sweden
Fellow of the British Pharmacological Society
Fellow of the Higher Education Academy
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