You are here:

Biotech & Biomedical/PEG 400 pharmacokinetics

Advertisement

Expert: - 2/10/2004


Question
Dear Dr.Skett,

I´m using PEG 400 90% and DMSO 10% as a vehicle, due to problems regarding drug solubility  (subcutaneous administration, 250 uL, in mice). Could you please answer me if PEG 400 is well absorbed by subcutaneous route? I expect that the drug reaches high plasma levels at 45 minutes to 1 hour post administration. Thank you in advance for any help.

Answer
Rodrigo,

Thanks for your question.

I would doubt that much of the PEG 400 is taken up - I assume you mean into the plasma.

DMSO certainly is and rapidly but the chemical nature of PEG 400 would suggest that this is not absorbed.

Is there any indication that it is?

Best wishes,

Paul

Biotech & Biomedical

All Answers

Answers by Expert:

Ask Experts

Volunteer

Dr.Paul Skett

Expertise

drug metabolism or biotransformation from basic to advanced, hepatocytes from basic to advanced, drug toxicity and side effects, alcohol clearance and levels

Experience

32 years research experience in above areas, 30 years educational experience in University. Retained expert for numerous legal firms dealing with matters of drugs (legal and illegal)and alcohol.

Education/Credentials
B.Sc(Hons) Biochemistry, University of Liverpool, UK
fil.dr. (Medical Chemistry) Karolinska Institute, Stockholm, Sweden

Fellow of the British Pharmacological Society

Fellow of the Higher Education Academy

©2012 About.com, a part of The New York Times Company. All rights reserved.