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Biotech & Biomedical/Questions Answered by Expert Dr.Paul Skett
| Subject | Date Asked |
| 5-HTP potency | 6/7/2011 |
| Q: I purchased 6 bottles of Hydroxytryptophan in capsule form--all natural made from "Griffonia ... A: Robin, 5-HTP is not particularly heat labile (i.e it can survive a bit of heat if dry) but storage ... | |
| Coca cola | 3/31/2011 |
| Q: A friend of mine likes to regularly quote from the following article on the effects of drinking a ... A: Paul, Thanks for your question. Where do I start!? Individually each of the components mentioned ... | |
| death | 2/5/2011 |
| Q: ...it is kind of a strange one. I am a pastor who is writing a sermon on death. I know that that ... A: Pete, Thanks for your follow-up question. Sorry it has taken so long to get back to you -I am a ... | |
| death | 2/4/2011 |
| Q: ...it is kind of a strange one. I am a pastor who is writing a sermon on death. I know that that ... A: Pete, Thanks for your question - interesting one! In fact, the body does NOT stop using oxygen ... | |
| Methadone excretion | 12/1/2010 |
| Q: I take methadone for MS-related pain, and because it works very well, I rarely miss a dose. However, ... A: Marcia, Thanks for your question. Yes, a UTI can significantly affect urinary pH and methadone ... | |
| 'positive' and 'negative' predictability? | 10/29/2010 |
| Q: could you please tell me what is meant by the terms 'negative predictability' and 'positive ... A: Cathleen, Thanks for your question. Predictability is the measure of how good the test is of ... | |
| false positive on hair alcohol test urgent! | 9/1/2010 |
| Q: for purposes of regaining custody of my daughter I recently had a hair alcohol test, to detect EtG ... A: Cathleen, Thanks for your follow-up question. These results are all about iron in the body. Your ... | |
| Tolerance, Metabolism, not getting absorbed properly, or a combo? | 8/11/2010 |
| Q: Well long story short: I've been on a bunch of different medications for many different reasons. ... A: Russell, Thanks for your question. Sounds like a combination of a number of factors here - whilst ... | |
| THE HCG PRODUCT | 7/7/2010 |
| Q: CAN YOU ENLIGHTEN ME ABOUT THIS PRODUCT/PROGRAMME BEING USED FOR WEIGHT LOSS? IS IT SAFE? ARE ... A: Arlene, Thanks for your question. hCG is a hormone which is produced in the female during ... | |
| Legal highs | 5/20/2010 |
| Q: I'm a student doing some research on drugs and drug-use, and would like to find out how the term ... A: Lawrence, Thanks for your question. I have been dealing a lot with these particular substances ... | |
| Cure | 3/25/2010 |
| Q: I am a student in highschool, and I am curious to know from an expert, which field of medicine would ... A: Drake, Thanks for your question. The idea of a "cure" is actually quite a difficult one. You need ... | |
| Hair strand test results | 2/22/2010 |
| Q: I recently submitted to a hair strand test as I had been accused of consistently abusing alcohol. ... A: Ed, Thanks for your question. Hair analysis is only good for saying if something is present - i.e ... | |
| Hair alcohol detection | 2/18/2010 |
| Q: I'd like some information regarding hair alcohol profiling, particularly regarding accuracy and ... A: Paul, Thanks for your question. This test measures the levels (or presence) of ethyl glucuronide ... | |
| Anabolic Cream | 9/19/2009 |
| Q: .. is it possible to make a cream with antiseptics & anabolics to get faster the heal of wounds... ... A: Aide, Thanks for your question. With the correct formulation you can make a cream out of virtually ... | |
| omega 3 deficient | 8/22/2009 |
| Q: Until a few years ago, I have basically lived my life with literally no omega 3 consumption. I am ... A: Xavier, Thanks for your question. It would be very difficult to work out what, if any, effects ... | |
| Methadone Level | 8/3/2009 |
| Q: I have a friend whose methadone level on her last drug test was 3614. Is this a high level? Is ... A: LaDonna, Methadone can be (and is) used long-term - it is used in Scotland for years at a time and ... | |
| Methadone Level | 7/31/2009 |
| Q: I have a friend whose methadone level on her last drug test was 3614. Is this a high level? Is ... A: LaDonna, This is a high and potentially life-threatening level (depending on the tolerance of the ... | |
| biotechnology | 6/23/2009 |
| Q: sir,i had finished my graduation in biotech.i want to join for higher education.can you please ... A: Maya, In general Biochemistry would be a better option as it is more general and gives you a ... | |
| new nano technology | 6/2/2009 |
| Q: have read articles on this as a new superior form of medicine delivery and supplementation ... A: Peter, As with all new technology, nanotechnology has the potential for great good or to be abused ... | |
| Theophylline half life | 4/6/2009 |
| Q: Why is the half life of theophylline shorter in young children than adults? A: Clare, Thanks for your question. Two main reasons: 1. The enzyme that clears theophylline ... | |
| dichlorovos | 2/9/2009 |
| Q: thankyou for your time A: Mariam, Dichlorovos interacts with the serine residue in the active site of acetylcholinesterase at ... | |
| Stress and the BBB | 12/4/2008 |
| Q: Dr. Skett, I'm looking to find out if there are drugs, recreational or pharmacological, that would ... A: Jennifer, Thanks for follow-up question. One good example is penicillin - thus, can be used in ... | |
| Stress and the BBB | 12/3/2008 |
| Q: Dr. Skett, I'm looking to find out if there are drugs, recreational or pharmacological, that would ... A: Jennifer, Thanks for your question. Stress (mental) doesn't do much to the BBB. Needs to be ... | |
| BECKER MUSCULAR DYSTROPHY GENE | 12/1/2008 |
| Q: CAN MUSCULAR DYSTROPHY PEOPLE TAKE CLARITHROMYCIN 500MG BY IV DRIP IF THEY ARE ALLERGIC TO ... A: Lynn, Short answer - no. Clarithromycin is closely chemically related to erythromycin and almost ... | |
| fraud | 11/2/2008 |
| Q: I hope this is part of you're expertise or you can help because I'm not sure who else to ask. I was ... A: Jon, Interesting question! Whilst many pharmaceutical products can lead to drug dependence, no ... | |
| morphine - follow up | 10/19/2008 |
| Q: First, I hope you might help me understand something about oral vs. parenthal dosing of morphine ... ... A: Th, This must have been a pretty bad time for you. I' m sorry. As to eye colour, there is very ... | |
| blood brain barrier | 10/10/2008 |
| Q: i need your help in making a list of drugs that can cross blood brain barrier,i only have a few to ... A: Sabiya, Thanks for your question. Relatively easy - any drug that is designed to be given orally, ... | |
| morphine | 10/7/2008 |
| Q: First, I hope you might help me understand something about oral vs. parenthal dosing of morphine ... ... A: Th, Thanks for your question. First let us look at the difference between oral and i.v. morphine. ... | |
| inhalation, ingestion eye exposure. | 9/12/2008 |
| Q: Dr. Skett What would an inhalation, ingestion exposure as well as to the eyes of Butane, Diethylene ... A: Janice, I am sorry to hear of your husband's accident and injury - some of the permanent effects ... | |
| inhalation, ingestion eye exposure. | 9/10/2008 |
| Q: Dr. Skett What would an inhalation, ingestion exposure as well as to the eyes of Butane, Diethylene ... A: Janice, Some very nasty chemicals in this list! Sodium hydroxide is a very caustic substance - ... | |
| Acne Vaccine | 9/2/2008 |
| Q: I would like to know if the acne vaccine is available anywhere? Would you please let me know where i ... A: Ingrid, Apologies for the lateness of the reply - I was away on holiday and forgot to set my ... | |
| Blood analysis | 7/24/2008 |
| Q: We are enquiring in regard to whether or not there is any test which can differentiate two blood ... A: John, Thanks for your question - sorry about delay in answering - family emergency took me away ... | |
| Query related to biochemists future | 6/25/2008 |
| Q: I am doing my B.SC biochemistry. I would like to know the Scope of this course. I have an idea to do ... A: I assume you are asking what careers you can follow with such a degree. The Biochemical Society ... | |
| bioanlytical | 5/24/2008 |
| Q: sir, when we do liquid liquid extraction what is effect of adding 10%acid or any base and how do ... A: Simi, I assume you are using extraction to/from an organic solvent from a water-based one. The ... | |
| bioanalytical | 5/23/2008 |
| Q: sir i would like to know howthecalculation is doing for a drug to be bioequivalent with other?and on ... A: Simi, To be "bioequivalent" two preparations or drugs need to give the same biological effect. The ... | |
| G6PD deficiency and menthol | 5/18/2008 |
| Q: i was informed by my pedia that g6pd patients should avoid menthol products, so i bought a ... A: Sorry it has taken so long to get back to you - I am examination marking just now! Anyway - no, I ... | |
| methadone urine test | 5/7/2008 |
| Q: I am successfully living with chronic pain, college full-time with a 4.0 average, my writing is ... A: Elizabeth, First congratulations on living a full and active life despite what must be difficult ... | |
| G6PDD | 4/5/2008 |
| Q: are these chemicals prohibited to G6PDD babies-dimethicone,isopropyl ... A: Anoj, Thanks for your question. The compounds you mention are nearly all common constituents in ... | |
| bioanalytical | 3/19/2008 |
| Q: my question is how does the conentration of drug in human plasma defined? i mean wheter the drug is ... A: Unfortunately, there is no easy, single answer to this question as every drug differs! Some drugs ... | |
| Deep Kissing & Sucking | 2/23/2008 |
| Q: Is HIV transmitted thru Deep Kissing( I was involved in deep kissing that is tongue to tongue ... A: Prashanth, Thanks for your question. Whilst the HIV is found in saliva of infected individuals, it ... | |
| DNA alteration | 11/26/2007 |
| Q: Is it possible to alter a person's blood type at birth or at any other time? Can all the blood be ... A: I suppose by altering the DNA in the blood stem cells, you could alter blood type - if you did this ... | |
| DNA Alteration | 11/26/2007 |
| Q: Can you alter a persons blood type at infancy or at any other time? Is it possible to change all or ... A: I suppose it is theoretically possible to alter the genetic make-up of the blood stem cells and then ... | |
| molecular mechanism of drug addiction/dependence | 7/27/2007 |
| Q: Why is buprenorphine less addictive than other opioids (like fentanyl) - is it explainable by its ... A: Miguel, Thanks for your question. Buprenorphine is what is referred to as a partial agonist - i.e. ... | |
| biomedical or biotechnology has brighter future? | 6/29/2007 |
| Q: i'am going to take a biological science course this july,in international Islamic university in ... A: Izzah, It is not clear what country you are in and, thus, I will answer as if you are in the UK. ... | |
| Lupus/Hughes Syndrome | 6/26/2007 |
| Q: I'm an 82 year old male diagnosed as above. I've used prednisone (more or less as needed) and ... A: Leonard, Thanks for your question. I assume this is a change in medication sanctioned by your ... | |
| biomedical or biotechnology has brighter future? | 6/19/2007 |
| Q: i'am going to take a biological science course this july,in international Islamic university in ... A: Izzah, Both of these courses can lead to a whole range of careers - the biomedical and ... | |
| Job Opportunity BioChemistry/BioTechnology | 6/11/2007 |
| Q: I have done my Ph.D programme in BioChemistry and have got professional exposure in molecular ... A: Nisha, Thanks for your question. I fully appreciate the frustration of not finding a suitable ... | |
| Phenoxyethanol | 5/18/2007 |
| Q: Is Phenoxyethanol harmful? I read some place it's toxic when absorbed through the skin but it ... A: Yael, You will find some websites claim that phenoxyethanol is harmful and can be absorbed through ... | |
| phenoxyethanol and shea butter | 1/9/2007 |
| Q: is lanolin or wool alchohols in these? i am alergic and there are so many hidden names,it is hard to ... A: Lisa, Thanks for your question. It can, indeed, be very confusing to work out what is in natural ... | |
| Alcohol Intoxication | 11/6/2006 |
| Q: Tks for your information. I am wondering, would it be within the scope of the biomedical expertise ... A: again, Theresa, Thanks for the nice comments! An expert witness would take everything within their ... | |
| Alcohol Intoxication | 11/6/2006 |
| Q: I want to dispute a coroner's finding that "acute alcohol intoxication" caused the deceased to fall ... A: Theresa, I am sorry to hear of your troubles - such decisions can be difficult to take. This is a ... | |
| Study of Biomedical Sciences | 8/4/2006 |
| Q: What is the definition of Biomedical What topics covers the Study of Biomedical Sciences A: Gilbert, The term "biomedical" covers a vast range of subjects - everything that relates biology to ... | |
| New IND and estimated dose for children | 7/31/2006 |
| Q: Do you know how the dose for children is being estimated based on preclinical data? A: Uwe, There are a number of ways of estimating children's doses from preclinical (adult) data - ... | |
| M-17 e.coli and b.infantis.. can I mix them? | 7/13/2006 |
| Q: I'm currently taking b.infantis (a probiotic for IBS made by Proctor & Gamble, brand name Align) and ... A: Will, Thanks for your question. The gut flora is made up of a whole host of different bacteria, ... | |
| drug-plasma protein binding | 2/7/2006 |
| Q: We have measured the percentage of a drug that is being bound by plasma protein by equilibrium ... A: Uwe, Thanks for your question. This is more an experimental design question than a pharmacology ... | |
| drug induced autoimmune syndrome | 11/28/2005 |
| Q: My daughter took Minocycline for 18 months with no problems. She had a Hepatitis A vaccine and then ... A: Jennifer, Thanks for your question. I am sorry to hear of the problems with your daughter. As you ... | |
| Pharmacology Essay | 11/15/2005 |
| Q: Essay Title = Discuss the importance of drug metabolism in limiting the pharmacodynamic effects of ... A: Neil, Thanks for your question. If I was answering this question, I would include the following: ... | |
| hepatocyte protectors | 10/18/2005 |
| Q: Laennec cirrhosis is a common item around the population of third world ,lipids are accumulated ... A: Can I check what you are asking - are you saying that alcohol consumption in the presence of protein ... | |
| Are these harmful? | 9/30/2005 |
| Q: http://hazmap.nlm.nih.gov/cgi-bin/hazmap_generic?tbl=TblAgents&id=1223 ... A: Amanda, I have had a look at the sites mentioned. They are the standard US sites for all hazardous ... | |
| Are these harmful? | 9/29/2005 |
| Q: I am a huge fan of Pantene, but today I heard something rather alarming. Three of the chemicals ... A: Amanda, Thanks for your question. I have done a bit of research on this for you - where did you ... | |
| essays in med school | 8/15/2005 |
| Q: Do you have any suggestions for what type of book?Hi Dr. Paul I hope I'm finding you in the best of ... A: Jeff, Try the original, The Mind Map Book: How to Use Radiant Thinking to Maximize Your Brain's ... | |
| essays in med school | 8/14/2005 |
| Q: Paul I hope I'm finding you in the best of health.I have one final question that will make up my ... A: Jeff! Thanks for your questions concerning Med.School. You are right to get these sorts of things ... | |
| medical care | 5/9/2005 |
| Q: if some functions of your liver are not functioning properly what things should you avoid eating e.g ... A: Zahid, Thanks for your question. A very complicated question unfortunately. The liver performs so ... | |
| as a student in biochemistry... | 5/7/2005 |
| Q: as a student in biochemistry and biomedical what will he study A: Teresa, Thanks for question. This will depend a lot on where the course is being run (courses with ... | |
| i just want to know what biomedical... | 5/6/2005 |
| Q: i just want to know what biomedical and biochemistry are A: Teresa, Thanks for your question. Biochemistry is the study of the chemistry of how the body works ... | |
| Phenoxyethanol | 9/4/2004 |
| Q: Hope i'm asking the right person! Sorry if i'm not. We have a goldfish, not too long ago he ... A: Danny, Apologies for taking so long to get back to you - I have just returned from an overseas ... | |
| PEG 400 pharmacokinetics | 2/10/2004 |
| Q: Skett, I´m using PEG 400 90% and DMSO 10% as a vehicle, due to problems regarding drug solubility ... A: Rodrigo, Thanks for your question. I would doubt that much of the PEG 400 is taken up - I assume ... | |
| pharmeceutical business | 12/4/2003 |
| Q: Skett - I don't know if you can answer my question, but here goes: I'm wondering if there is a way ... A: Lee Anne, As you suspect, this sort of information is not freely available - generally, however, ... | |
| For the deailed molecular level | 9/17/2002 |
| Q: For that hydralazine is under acetylation,the slow acetylator people will have more chance to get ... A: Sinn, The mechanism of lupus from hydralazine is still unclear - most likely an autoimmune reaction ... | |
| BBB | 8/7/2002 |
| Q: Can you tell me why CNS drugs like amphetamine can cross the BBB of brain,some drugs cannot? A: Sinn, BBB is just that the cells lining the capillaries in the brain are pushed tightly together ... | |
| Antidepressant EFFEXOR from Wyeth-Ayerst | 9/13/2001 |
| Q: I was told by a friend that the 2 active ingredients in EFFEXOR have been specifically proven to ... A: Don, It is, indeed, true that the male and female brains are different - this is well documented ... | |
Biotech & Biomedical
Answers by Expert:
Dr.Paul Skett
Top Expert on this page
Expertise
drug metabolism or biotransformation from basic to advanced, hepatocytes from basic to advanced, drug toxicity and side effects, alcohol clearance and levels
Experience
32 years research experience in above areas, 30 years educational experience in University. Retained expert for numerous legal firms dealing with matters of drugs (legal and illegal)and alcohol.
Education/Credentials
B.Sc(Hons) Biochemistry, University of Liverpool, UK
fil.dr. (Medical Chemistry) Karolinska Institute, Stockholm, Sweden
Fellow of the British Pharmacological Society
Fellow of the Higher Education Academy
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