Breast Cancer/phyllodes tumor

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Expert: - 11/28/2009


Question
I am trying to decide if I should get radiation therapy after my simple mastectomy for malignant phyllodes tumor. Here is my path. report:
Malignant phyllodes tumor shows variation in stromal cellularity with periductal stromal condensation. The infiltrative border is relatively sharp. In areas stromal cells are associated with a chondromyxoid matrix, but no true heterologous sarcoma is identified. There is moderate to severe stromal cytologic atypia. Mitosis include occasional atypical forms. Stromal cells are diffusely CD117(c-kit) positive. This correlates with high tumor grade, but may not correspond to mutation of the c-kit gene. Uninvolved breast shows stromal fibrosis, cystic change, and intraductal hyperplasia.
Size:    3.6cm
Location:  left breast
Type: Malignant phyllodes tumor with stromal overgrowth.
Margins: Negative-closest (deep) margin is 0.7cm
Mitotic Activity: 3 mitosis per 10 high power fields

Thank you so much.

Answer
Well, if you were my patient I would recommend it based on among other things the size of your tumor.

I have some computer problems so unfortunately my reply is delayed.

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Claes-Gustaf Nordquist, M.D.

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I`m a doctor of medicine and a specialist in radiation therapy and medical oncology. I have long experience in diagnostics and treatment of breast tumours.

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I'm a Doctor of Medicine and specialist in Medical Oncology and Radiation Therapy educated & trained in Sweden. Now retired. Background in Radiation Therapy, Medical Oncology, Radiation Protection, Nuclear Medicine, Diagnostic Radiology, Gynecological Oncology, Clinical Pathology, Clinical Cytology,Hematology and Internal Medicine. M.D. from the faculty of medicine, Royal Karolinska Institute, Stockholm, Sweden. Have also been an exchange student at the Hebrew University, Hadassah Medical School, Jerusalem Israel. Former medical consultant, Swedish National Board of Radiation Protection. Former Police Surgeon and Medical Examiner, Stockholm Police Department. Former Chief Medical Officer, The Royal Guards, The Royal Horse Guards and the Royal Household Brigade, Royal Swedish Army Medical Corps.You can also reach me on: http://www.lifestylerescue.com/expert/health-fitness-advice/dr-claes-gustaf/128 I have no restrictions on the number of questions there.

I also answer questions about Oncology (General Cancer), General History, Military History, Brain Tumors, Colon Cancer

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I'm a medical doctor and specialist in medical oncology and radiation therapy.

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