Expert: Claes-Gustaf Nordquist, M.D. - 1/8/2007

Question
Thanks - on the hormone after radical surgery therapy being ok.. can you point me to some articles please I can't find any.  So they would be articles on removing both breasts and both ovaries and the uturus and then adding small daily doses of natural hormonal therapy. This would be for an individual would be EP PR positive. That would be of great help because I just can't find anything articles and NO one seems to know.  Thanks again for all you do!

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The text above is a follow-up to ...

-----Question-----
OK  So you asked me to keep you informed and here goes.  It's good news (if that's possible when it comes to a cancer diagnosis)  DCIS Stage O.  Needle biopsy showed intermediate to high grade ductal carcinoma insitu cribiform with comedonecronsis and focal microcalcification, present on multiple cores.  (1.5 cm)
Estrogen Positive 90% and Progesterone Positive 80%
This almost replicates my mothers breast cancer that she passed from however she was well passed this stage.

Now..  I believe I am going to have a lumpectomy and a tamoxifem type therapy(i am still peri-meniposal).  So am I wrong not to choice radiation in conjunction?

If I choose complete mastectomy of both breasts and reconstruction (plus the removal of my last overy) would it be possible for me to go on some sort of natural hormonal replacement therapy for my future bones and health?

How about HER2 in early stage breast care?

Thanks in advance for any information you might add to these and any other thoughts you might have.

Best - Mary  and thanks!

-----Answer-----
If you do NOT choose mastectomy I STRONGLY SUGGEST that the lumpectomy & anti hormonal therapy (tamoxiphene) should be complemented by radiation therapy (regular procedure in France with just as good results as in mastectomies). If you choose bilateral mastectomy etc., I see no reason why you should not be able to be on hormonal replacement therapy, but do discuss it with a cardiologist, due to possible cardio-vascular complications. Good luck!


Answer
Honestly I know of no articles on the whole procedure (breasts, uterus, ovaries etc.). My personal knowledge on these matters come from many & long discussions with the surgeons - since the surgery part of the therapy was not so to speak "my thing" if you pardon the expression. I think you should direct this question to a breast surgeon and a gynecological surgeon. Or to experts on these matters here.