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Cats/cranky older cat

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Question
I have 5 cats that are indoor/outdoor cats.  They are all very playful and happy except for my calico female cat named tootsie.
She is approximately 5 years old and is just miserable.  (well happy when she is sleeping in my lap but that's about it)  she hisses instantly at everyone and fights with all the other cats.  She just is starting to act really weird by not wanting to go to the basement for her food/ kitty litter and starting going to the bathroom in weird places.  she sits on the counter and just looks really not happy and kinda "out of it" .  
any advice would be great.

Answer
Melissa,

These are all signs that your cat is sick. Your cat needs to see a veterinarian promptly. Based on the signs you describe if she were mine I would have her in to see the vet immediately.

If you have any further questions or concerns, please don't hesitate to contact me again. I'm more than happy to help in any way that I can.

Kind regards,

Ali

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Ali

Expertise

I am the proud guardian of 5 mixed breed cats ranging from 12 weeks to 13 years old and one purebred ragdoll. I have 20+ years experience working with mixed breed cats from a variety of different situations. I have fostered cats/kittens with special needs/behavioral issues. I have rescued/rehabilitated/re-homed a variety of stray/abused cats. I can offer advice on managing feral cat colonies, rehabilitating strays and finding them forever homes. I can help you to determine whether a cat is stray or feral, there IS a significant difference. Improperly introducing a new cat/kitten can result in aggression between newly introduced cats because cats are territorial by nature and they don't like sudden changes in their environment. To learn more about a peaceful way to introduce a new cat into a home with other cats please check out my previous answers on this subject. Proper nutrition for cats can be confusing, I recommend checking out catinfo.org which was created by a veterinarian (Dr. Lisa Pierson) who takes a common sense approach to explaining feline nutrition. Cat behavior and instincts are different from those of humans, I can help you understand your cat's needs so that you can meet them adequately and have a balanced, psychologically and physically sound kitty. Cats vary in personality, energy level and intelligence, different approaches may be required to achieve results in terms of training and interaction with your feline companion. An intelligent, high energy cat must be kept busy or they will make their own fun. I am NOT a licensed veterinarian and I can't offer medical advice. If your cat is ill/injured my advice is always the same: get prompt medical treatment provided by a veterinarian. If finances are an issue I will try to find resources in your area that can help with medical costs or make other choices to ensure the welfare of your cat.

Experience

I have fostered feral and stray cats, rehabilitated and homed cats that many people recommended euthanasia for. I am willing to make an effort to do the research and ask questions because I care enough to find solutions to behavioral problems rather than giving up. I have an interest in the use of alternative therapies to help provide the best possible care for all cats and I can say in all honesty that I've seen some incredible things happen for some incredible cats and their human caregivers when the right alternative therapeutic modality is used by a qualified veterinarian with expertise and experience in the field.

Education/Credentials
I've earned my diploma as a veterinary assistant with honors.

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