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is there any reason you can think of as to why HPLC-MS might be more appropriate for testing a pharmaceutical preparation for trace metals than ICP-AES or ICP-MS? these could be sociological, economic or scientific in nature, i find it hard to believe that there is no case for HPLC-MS whatsoever but nobody else seems able to provide an argument.
If you have a preparation that is contaminated with metals, you may want to know which component is associated with the contamination. Is it the intended product, a side product, a filler agent, or a contaminant in the procedure. If you run HPLC-MS and say the contamination is mercury, the isotope patterns of the different peaks will quickly tell you where the mercury is located. It will also show if prep-HPLC can remove it and may tell you the structure of the organic the metal is associated with. It may show the metal is just present as a salt (if not associated with organics). Now if you just want to know where the metal is, HPLC-ICP-MS would be the technique.
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| Comment | the first person who's been able to give me a useful answer on this topic, much appreciated!!! | ||
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Answers by Expert:
Dr. Henry Boyter, Jr.
Expertise
No homework, biochemistry, or other schoolwork! The question will be rejected. If you have not searched www.google.com, do so before posting. If you are a student, give your grade and course. Everyone, explain the purpose and context for the question.
Experience in the area
Chemistry (non-biochemistry), environmental science, occupational health and safety, environmental regulation and management, environmental engineering, and wastewater engineering. I'm the Director of Environmental, Health, and Safety and the Director of Research at the Institute of Textile Technology.
Experience
Chemistry (non-biochemistry), environmental science, occupational health and safety, environmental regulation and management, environmental engineering, and wastewater engineering. I'm the Director of Environmental, Health, and Safety and the Director of Research at the Institute of Textile Technology.
Education/Credentials
PhD, MS, BS in Chemistry
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