Computational Biology / Bioinformatics/Blood Type

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Question
I have a question and I really need help.  My mom is O+ and my father was O- and I am A+.  Can you explain how this happened or did I get switched at birth some how?  Or in other words, should I look into alternative solutions?  My father passed when I was 10 and my mother swears she never messed around.  She is also paying for a paternity test on Monday to find out, between her and I.  I'm just curious if I should be really worried!?

Thank You!
Ronda

Answer
Rhonda,

 Thanks for your question.  First, a little explanation for blood types.  Blood types are composed of two factors:  the type itself (A, O,  B) and the Rh factors (+ or - ).  According to traditional blood type calculation, two parents with type O blood can only produce a type O offspring.  In order for an individual with an O type to produce an A type offspring, the other biological parent must be of blood type A or AB.  Hope that helps.

EDIT:
You are correct.  There is a very rare occurrence called the Bombay phenotype, where an individual has the hh blood group.  Because people with the Bombay phenotype can not create A or B antigens, they are usually tested as blood type O, resulting in a false typing.  Sorry for the oversight.

Computational Biology / Bioinformatics

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Sophia Jane Carter

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I can answer basic questions related to heritable diseases, and moderate level questions regarding genetics and biology in general. Please, no questions on what your future children will look like. I will happily answer questions regarding the inheritance of hair or eye colour, genetic diseases, genetic traits, etc..., but anything phrased as "I look like X and my partner look like Y; what will our baby look like?" will be sent to the question pool.

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For a year I served as a intern in a plant genetics laboratory, in addition to having completed a very tough biology curriculum.

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I have a BA in anthropology (focus on biological anthropology) from UC Berkeley.

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