Family, Internal Medicine, General Medical Questions/treatment alternatives
I have been taking lipator for four or five year but would love to find an alternative to statin drugs. What is the safety and efficacy of red rice yeast as compared to statins?
Question 2- I am a reasonably healthy 57 year old female with osteoarthritis (knees, degenerative disc disease, lots of osteophytes),intermittent itchy arms, chronic post nasal drip despite normal allergy testing and lichen sclerosis dx 23 years ago. Lichen sclerosis has become difficult to control since menopause. Now I am using clobetesol, vagifem, protopic. The past year, I have been plagued with atypical yeast infection controlled by flucozonale but returns when I stop it for more than a few weeks. I am using cpap for apnea but am still tired. I recently had a fatigue profile which included looking at hormone levels, thyroid etc. The numbers were all normal with the exception of sed rate (42) alk phos (121) vitamin d 23.9.
What are the implications of these numbers?
Do you have any suggestions for the treatment of my chronic health problems?
With regards to Question #1 about statins:
You will find you answer to ''statin'' therapy and the natural statin in extracts of red yeast rice. Additional alternative which are better are also listed. This is the 2nd part of a 2 part series on Cholesterol and Statin due to be published in American Fitness in the upcoming months. I have cut and pasted it here:
Cholesterol & Statins: Part II
by Yusuf M. Saleeby, MD
In the last issue (Cholesteron & Statins : Part I, American Fitness xxx 2013), the discussion centered on cholesterol, that necessary but often maligned molecule. The previous article made one realize that this steroid compound is a double edged sword as it relates to health concerns. While essential for the life of human cells, high serum levels of total cholesterol and in particular elevated non-HDL-cholesterol, designated bad cholesterol, end up being harmful to our cardiovascular system.
Plenteous research, time and money have been devoted to the study of this low density lipoprotein substance that carries cholesterol (LDL-C) out of the liver to cells. It was discovered that too much would ‘’clog up’’ arteries back in the 1970s. This was the driving force for aggressive development of medications to combat the formation and lower the level of LDL-C in circulation.1
As previously mentioned in Part I, dietary restriction of cholesterol is of limited value. When we limit our oral intake of dietary cholesterol, our body produces cholesterol in the liver to compensate for a predetermined genetic set point. Thus a cholesterol restrictive diet alone is usually not enough to reduce markedly elevated levels of the ‘’bad cholesterol.’’ 2 Dietary restrictions alongside weight loss and exercise are a more effective approach. Lipid lowering medications like the class of statin drugs have a more potent affect.
Statins or HMG-CoA reductase inhibitors are a class of drug that inhibits an enzyme which plays a central role in manufacturing cholesterol in the liver. The term ‘’statin’’ is derived by the last few letters of some of the original drugs developed, lovostatin and simvastatin being examples. Historically, the Japanese biochemist Dr. Akira Endo isolated the first statin drug (mevastatin), but it showed toxicities and never made it to market. Not long afterwards in the early 1970’s researchers from Merck pharmaceuticals following up on published research and developed the first marketable statin (lovostatin) which was extracted similar to Dr. Endo’s from the fungus (Aspergillus terreus).1,3 Incidentally, there are naturally occurring statins, namely those found in the oyster mushroom (Pleurotus ostreatus) and the extracts from fermented red yeast rice fungi (Monascus purpureus).4 This latter extract is used commercially as a natural alternative to reduce cholesterol.
Merck capitalized on the statin drugs Zocor® and Mevacor®, which earned the company over $1-Billion each by 1995. Dr. Endo was also the beneficiary of the 2006 Japan Prize and Lasker-DeBakey Clinical Research Award in 2008 for his achievements in the field of lipid chemistry. Today there are a number of statins in the marketplace, as both stand alone drugs and in combination with other lipid lowering agents. Names the public would recognize include Lipitor® (atorvastatin), Lescol® (fluvastatin), Mevacor® (lovastatin), Pravachol® (pravastatin), Crestor® (rosuvastatin) and Zocor® (simvastatin). All are lab synthesized drugs except for lovastatin and pravastatin which are derived directly from naturally occurring yeast and bacterium.
Statin Drugs (HMG-coA reductase inhibitors)
Numerous medical trials show the statins as having a major affect on lowering LDL-C, and thus bringing the total cholesterol in serum down. Statins can, with varying degree raise HDL-C levels. When compared to diet alone, statins are proven more effective in lowering LDL-C. However, this is not accomplished without some undesirable side effects. The drugs mostly affect the liver hepatocytes and muscle cells. The toxicity of natural occurring statins in mushrooms is unobtrusive, but some serious muscle damage can occur with pharmaceuticals. One such incident occurred when Baycol® (cerivastatin) came to market some years ago. It was so toxic that the Federal Drug Administration (FDA) had to remove it from pharmacies in 2001.5
Recent changes to the National Institute of Health (NIH) guidelines for testing individuals now suggest that children between the ages of 9 to 11 have lipid screening performed. Most statins are approved for use in children 10-years and older, but use should be judicious. Statins are classified as Category X in pregnancy which means they are contraindicated in expectant women because of high risk of birth defects.6
Statin drugs produce muscle pain in approximately 30-percent of individuals who take them. Other side effects include liver damage, digestive problems, rash, cataracts, an increase in blood glucose and type-2 diabetes (T2DM) risk, and neurological conditions as a rise in amyotrophic lateral sclerosis (ALS) incidence. Those that are at higher risks are females, those taking other cholesterol medications, people with small body frames and with underlying kidney or liver disease and/or diabetes. Being over the age of 65-years also increases risk for untoward effects for statin users. There are reports of a fifty-percent increase in risk of developing age-related cataracts with those using statin drugs compared with non-users.5,6,7
To combat detrimental side effects, sometimes a prescriber will switching from one statin to another, or reduce the dose, or change the dosing schedule to every other day. If a person is taking a statin they should avoid grapefruit and grapefruit juice as this can potentiate the drug’s harmful effects. The cardiac rhythm drug amiodarone (Cardarone®) has an interaction with simvastatin. Lopid® another lipid lowering agents concomitant use with statins is ill advised. Some HIV drugs (protease inhibitors) interact with lovastatin in a negative way. There are even interactions with antibiotics and antifungal drugs. The immunosuppressant drug cyclosporine (Sandimmune®) can increase risk for rhabdomyolysis (muscle breakdown) as well.5,7 With statin use monitoring of liver function tests (transaminases) and muscle biomarkers creatine kinase (CPK) and aldolase are indicated routinely along with monitoring the effects of the drug to meet goal (serum LDL-C and ApoB levels). Yet other measures to reduce untoward effects of statin drugs have been to add coenzyme Q10, correct Vitamin D and thyroid deficiencies, or switch to a non-statin regimen. There is a theoretical risk that lowering cholesterol drastically can affect production and levels of beneficial steroid hormones. More study in this area is needed to confirm or dispel fears.
Since the mapping of the human genome, genetic tests have been developed to help predict coronary risk and the effectiveness of statin therapy. The blood test analyzing the KIF6 genotype (offered by Berkeley Heart Labs) may aid doctors in directing lipid therapy as polymorphisms in this gene identify those at higher risk for coronary heart disease. Once identified, those individuals can reduce their risk with statin therapy. The SLCO1B1 genotype test, help clinicians predict who may be at greater risk for muscle damage while on lipid lowering therapy. Carriers of the SLCO1B1 gene are more likely to have problems with statin induced myopathy then those who do not carry that gene.8,9
With the drug market eventually becoming saturated with statin medications and coming under fire with a plethora of side effects, researchers began looking elsewhere. Focus was centered on manipulation of beneficial lipoproteins, namely HDL-C. It was reasonable to think that raising HDL-C would scavenge the bad cholesterol away to be recycled and thus not be around to form foam cells. Research had already proven that reduction in native LDL-C and foam cells, which lead to arterial plaque formation, would lessen the risk for heart disease. A genetic malady, albeit rare gave promise that developing pro-HDL-C drugs may be a superior alternative to statin therapy. Tangier Disease afflicts a very small number of people worldwide, but with extremely low levels of HDL-C there is a tendency for more advanced cardiovascular disease in younger victims.10-13 Initial trials of HDL-C raising drugs were a disappointment to those proponents of raising HDL, but research continues in this direction.14
In all fairness to statin drugs, there have been reports of other benefits such as improving endothelial function, reducing inflammatory C-Reactive Protein, coronary plaque stability and reduction in thrombus formation (clots). Additionally, for reasons not quite clear there was a reduction in cancer risk while study subjects were on statin drugs.15,16
According to an October 2012 JAMA report on trends in lipids in the United States between 1988 and 2010, total cholesterol and LDL-C numbers experienced a reduction. Unfortunately during the same time frame triglycerides (TG) went up while HDL-C remained unchanged. This is all apparently the result of aggressive statin use with Americans having dyslipidemia.17
Pharmaceutical Alternatives to Statin Therapy
Ezetimibe a drug known in the US market as Zetia® is an alternative for those who cannot tolerate statin therapy. Ezetimibe can lower cholesterol by interrupting intestinal re-absorption of cholesterol. However, studies have reported continued use can thicken the arterial walls. So it is recommended as a drug of last resort by some. Ezetimibe is also used in conjunction with statins in some dual agent drugs such as Vytorin®. Dual therapy is a means of using two agents at lower individual doses to achieve a particular lipid level goal and limit side effects.18,19
Fibric Acid derivatives such as gemfibrozil (Lopid®) and fenofibrate (TriCor®) are other alternatives to statin therapy. While not as effective in lowering LDL-C as stains, they do raise HDL-C and lower Triglycerides (TG). Fibric Acid drugs are known to improving insulin resistance as an added benefit. However, in combination with statins they can increase risk for liver and muscle injury.20,21
Vitamin B3 (nicotinic acid) in high doses is commonly used to raise HDL-C. This naturally occurring substance while relatively safe in high doses does come with the undesirable side effect of flushing. Flushing can be thwarted by a delayed release delivery system (Niaspan®) by prescription and by premedication with low dose aspirin.22
Questran® and WelChol® are in a class of drug called bile acid resins. Bile acid resins are used to lower LDL-C and total Cholesterol by sequestration and expulsion in feces. They are effective and are another pharmaceutical alternative with limited systemic effects used in statin-intolerant patients.22
Cholesteryl ester transfer protein (CETP) inhibitors came on the scene recently. They were touted as the new wonder drug for cholesterol management, or so it was thought. This class of medication is used to raise HDL-C.12,13 However, initial attempts by Roche pharmaceuticals were halted in phase III trials due to failure of the agent (torcetrapid) to perform safely.14 Nonetheless, the Academy for the Advancement of HDL Science is optimistic about future developments and new drugs in the pipeline.15
Natural Alternatives to Statin Therapy
Fish oil is a clinically proven agent in lowering cholesterol and triglycerides. The omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are well researched as being effective for dyslipidemia. Krill oil is a newer arrival into the forum; it has been peddled as being better than fish oil by proponents. Having a lower DHA and EPA content than fish oil and costing 5 to 10-times as much, it may not be a preferred choice. Only a few high concentrated Krill or Krill/Fish oil combinations give you the necessary concentrations of DHA/EPA to lower lipids and provide cardiac risk reduction.23 Fish oil has the FDA nod of approval for lowering cholesterol and triglycerides (TG) and even comes as the FDA approved prescriptive Lovaza®. While Lovaza® is rather expensive; those seeking pharmaceutical grade fish oil have many less expensive choices that are equally effective and safe. Caution should be taken when using fish oil with other blood thinning medications prior to elective surgery or with those with seafood allergies.
Besides fish oil there are several herbal and dietary supplements that can lower cholesterol and heart disease risk. Garlic in some studies reported a reduction of total cholesterol by a few points. Caution however, must be taken when taken in conjunction with blood thinners such as Coumadin® as bleeding risks may increase.24 Oat bran and barley have been studied and demonstrate that with regular ingestion a person can lower cholesterol and cardiac risk.25
The resin Guggulipid derived from the mukul myrrh tree, illustrates a reduction of LDL-C and total cholesterol in clinical studies performed in India. Demonstrating Guggulipid to be an important natural lipid lowering agent will require more scientific examination. As mentioned earlier the extract of fermented red yeast rice is a naturally occurring statin. While showing lower risk of toxicity, there is a linear correlation with lower effectiveness due to its reduced potency. The product of the waxy coating of sugar cane and beet skins known as policosanol was shown in several clinical trials to lower LDL-C when taken orally in standard doses.24,26,27
Extracts of fenugreek, artichoke, yarrow, and holy basil may also help lower cholesterol, but again clinical trials will have to prove this to the medical community. The use of ginger, turmeric, and rosemary in cholesterol lowering preparations are common as there may be some benefit. Consumption of dietary fiber, soy based foods, and plant sterols (aka phytosterols, compounds similar to cholesterol) can reduce LDL-C. Phytosterols interfere with the re-absorption of cholesterol and can be found in commercial bread spreads like Benecol®, Promise®, and Smart Balance®.26,27 With the advent of ‘’Medical Foods” there are patented combination therapies, sanctioned by the FDA for prescriptive use, that have shown promise in scientific studies. Metagenic’s UltraMeal360® is an example of such a prescriptive medical food.28 Another medical food is Hypertensa® designed for those with metabolic syndrome by Physician Therapeutics; and more of these safer alternatives are on the horizon.29
Whether you put your chips on lowering LDL-C or raising HDL-C one important fact remains; both courses of action will reduce cardiovascular risk, but when you add weight loss and exercise then risk of heart disease really drops. According to Mayo Clinic reports, weight loss of between 5 and 10 lbs can lower LDL-C levels. For every six pounds of weight loss you can increase HDL-C by 1mg/dL in serum levels. Physical activity, as in sustained exercise, lasting 30 minutes or more at least five times a week can yield a five-percent increase in HDL-C. Smoke cessation is also a big player; quit smoking and you can increase your HDL-C by ten-percent and in a year reduce your heart disease risk by fifty-percent.26,27,30,31
Controlling cholesterol is a complicated process for physicians and patients alike. Wrought with drug tolerance, unproven alternatives, and cost issues, it is a daunting task to manage dyslipidemia. Along with ever changing practice guidelines for serum cholesterol levels offered up every couple of years by national medical societies and institutions, therapeutic recommendations will likely remain in flux for the unforeseeable future.
1. Endo A., The discovery and development of HMG-CoA reductase inhibitors, J. Lipid Res. 1992;33 (11): 1569–82.
2. Ahmed SM, Clasen ME, Donnelly JE. Management of dyslipidemia in adults. Am Fam Physician, 1998;1;57(9):2192-2204, 2207-8.
3. Simons, John. "The $10 billion pill", Fortune magazine, January 20, 2003.
4. Liu J, Zhang J, Shi Y, Grimsgaard S, Alraek T, Fønnebø V, Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials". Chin Med 2006;1: 4.
5. Golomb BA, Evans MA., Statin Adverse Effects: A Review of the Literature and Evidence for a Mitochondrial Mechanism. Am J Cardiovasc Drugs 2008;8(6): 373–418.
6. Prescriber’s Letter, January 2012 (vol. 19, no. 1) and June 2012 (vol. 19, no. 6) section on Statins and Dyslipidemia.
7. Statin Side Effects, Retrieved from http://www.mayoclinic.com/health/statin-side-effects/MY00205
8. SLCO1B1 Genotype testing, Retrieved from http://www.bhlinc.com/clinicians/test-descriptions/SLCO1B1-Genotype-Test
9. KIF6 Genotype testing, Retrieved from http://www.bhlinc.com/clinicians/test-descriptions/KIF6
, (Accessed 12/3/2012)
10. Grover SA, et al., Evaluating the incremental benefits of raising high-density lipoprotein cholesterol levels during lipid therapy after adjustment for the reductions in other blood lipid levels. Arch. Internal Med. 2009;169:1775.
11. Singh IM, et al., High-density lipoprotein as a therapeutic target: A systematic review. JAMA. 2007;298:786.
12. High Cholesterol: Cholesterol-lowering medication, Retrieved from http://www.webmd.com/cholesterol-management/guide/cholesterol-lowering-medicatio
, (Accessed 12/3/2012)
13. HDL Cholesterol: How to boost your ‘good’ cholesterol, Retrieved from http://www.mayoclinic.com/health/hdl-cholesterol
, (Accessed 12/3/2012)
14. "Roche provides update on Phase III study of dalcetrapib." Roche press release, May 7, 2012.
15. Academy for the Advancement of HDL Science, Retrieved from http://lipid.org
16. Ridker PM, Danielson E, Fonseca FAH et al., Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. NEJM 2008;359 (21): 2195–207.
17. Mitka M., Cholesterol drug controversy continues. JAMA 2008;299 (19): 2266.
18. Carroll, MD., et al, Trends in Lipids and Lipoproteins in US Adults, 1988-2010., JAMA, 2012;308(15):1545-1554.
19. Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, et al. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Proc Natl Acad Sci, 2005;102(23):8132-7.
20. Jun M, Foote C, Lv J, et al., Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet 2010;375 (9729): 1875–1884.
21. Steiner G., Atherosclerosis in type 2 diabetes: a role for fibrate therapy?. Diab Vasc Dis Res, 2007;4 (4): 368–74.
22. Alternative Treatments for High Cholesterol, Retrieved from http://www.webmd.com/cholesterol-management/guide/high_cholesterol_alternative-t
, (Accessed 12/3/2012)
23. Krill Oil: A substitute for Fish oil? Prescriber’s Letter August 2010, Retrieved from http://prescribersletter.therapeuticresearch.com
24. Cholesterol-lowering supplements: Lower your numbers without prescription medication, Retrieved from
25. Jenkins, D. [Oats bran and Barley on Cholesterol] American Journal of Clinical Nutrition, 2005; vol 81:pp 380-87.
26. Alternative Cholesterol Treatments, Retrieved from http://naturaldatabase.therapeuticresearch.com
27. Alternative Cholesterol Treatments, Retrieved from Cleveland Clinic Department of Nutrition and Cleveland Clinic Heart Center web sites (Accessed 12/3/2012)
28. Metagenics UltraMeal360®, Retrieved from http://www.metagenics.com/products/health-conditions/hypercholesterolemia
, (Accessed 11/16/2012)
29. Hypertensa® Package Insert, Retrieved from http://tmedpharma.com/docs/monographs-5-22/Hypertensa_Product_Monograph_for_webs
30. Smith SC Jr, Benjamin EJ, Bonow RO, et al., AHA/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update: a guideline from the American Heart Association and American College of Cardiology Foundation endorsed by the World Heart Federation and the Preventive Cardiovascular Nurses Association. J Am Coll Cardiol. 2011;58(23):2432-2446.
31. Greenland P, Alpert JS, Beller GA, et al., 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2010;122(25):e584-e636.
Yusuf (JP) Saleeby, MD is medical director of WellnessOne and WellnessFirst which offer extensive and advanced cardiovascular and stroke biomarker and genetic analysis, including lipid subtypes, Lp(a), CRP, HDL2 and HDL3, LDL1-4, ApoB, NT-proBNP, Lp-PLA2, and the 4q25, 9p21, ApoE, KIF6 and SLCO1B1-Genotype tests. He is a regular contributor to American Fitness and serves on the medical advisory board. He can be reached for comment at email@example.com.
With regard to your 2nd Question. It is far to complex and detailed to address in this forum. Should you reside in SC or close, you can visit me for an in-depth workup in my clinics in Myrtle Beach or Charleston, SC. If interested I can provide you with contact information.