About Nicholas Morphew Expertise I can answer simple genetics questions regarding probabilities of inheriting particular
diseases and anything that is a little trivial I can search the answers for. Please do not ask me
sensitive questions that you may not like an answer to - please consult your personal
geneticist or general practitioner.
Experience No practical experience
Education/Credentials Bachelor of Biomedical Science (University of Newcastle)
Expert: Nicholas Morphew Date: 1/11/2008 Subject: Chromosome Mapping
Question Is it possible to differentiate between a "bad chromosome" and a good chromosome by comparing the genetic chromosome maps of both chromosomes? And what are the benefits of chromosome mapping?
Answer Hi Tom,
From my knowledge, it is only detectable that there are serious problems with a chromosome when it manifests in the host - that is, they display obvious traits that are observable. Everyone has something that makes each of their genes within their chromosomes a little different from the next person - even if it is for the same gene! Also, to confuse the issue surrounding genes on a chromosome can also affect the performance of a nearby gene. This is why gene therapy is very touch and go and nothing is definite. We simply do not know enough about the genome. When you refer to chromosome 'maps' i'm assuming you are referring to a patients' genetic karyotype (all 23 pairs of chromosomes lined up for crude observance). This is for basic analysis and cannot pick up small mutations in genes etc.. it will only be obvious when large chunks from one chromosome is attached to another or simply observing the sex chromosomes of a person (y chromosome is significantly smaller than the x and can be observed at this level). A karyotype can confirm if there are additional or missing chromosomes and crude observances such as that.
