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Genetics/heterochromatin

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Question
what is the percentage of constitutive heterochomatin in a genome and how much it is expressed. is it possible that they can change to euchomatin

Answer
Hi Ujjal,

About 20%- 305% of the human genome is constitutive heterchromatin. Constitutive heterochromatin is  localized near centromeres and telomeres, CHr 1, 9 and 16 and Y chromomoes. Earlier they were considered devoid of transcribing genes but more recently, transcribing genes have been identified in drosophila. It is not known how much of it is expressd. CH do not changed to euchromatin but they may contain very few active genes.

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T

Genetics

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Thanemozhi Natarajan

Expertise

Answers in Genetics, genomics, cytogenetics of syndromes, congenital anomalies, cancer, clinical genomics and interpretation of omics data.

Experience

More than 10 years. Doctoral research thesis on Congenital anomalies and cytogenetics, Recurrent reproductive failure and chromosomal abnormalities. Postdoctoral experience in Breast cancer research. Current: Clinical Genomics and Pharmacogenomics.

Organizations
Academic

Publications
Cancer Cell International, Cancer Epidemiology Biomarkers and Prevention, Breast cancer research and treatment, Indian Journal of Pediatrics, BMC Proceedings, Pharmacogenetics and Genomics, Human Molecular Genetics, Frontiers in Genetics, Cancer Biomarkers.

Education/Credentials
PhD Biomedical Genetics

Awards and Honors
University Grants Commission Award for pursuing PhD level research (India); Travel awards to attend conferences.

Past/Present Clients
Post doctoral experience Cancer research, molecular epidemiology Current: Clininical Genomics and Pharmacogenomics

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