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Genetics/Genotype

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Question
How can two partners of the same genetype (AS) manage the situation without having a sickle cell genetyped child?

And again, what are other risks involved?

Many thanks

Answer
Hi Mr.Ogundipe,

It is necessary to have more information as to Genotype. If the partners are heterozygous, then they can go for an IVF and select an embryo with the normal genotype. If however both are homozygous, it would not be possible to biologically have a child with a normal phenotype. Alternatively, gene therapy in mice has been successful and may help humans.

When you talk about risks, could you elaborate your question as to risks under which condition?

Best.
T

Genetics

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Thanemozhi Natarajan

Expertise

Answers in Genetics, genomics, cytogenetics of syndromes, congenital anomalies, cancer, clinical genomics and interpretation of omics data.

Experience

More than 10 years. Doctoral research thesis on Congenital anomalies and cytogenetics, Recurrent reproductive failure and chromosomal abnormalities. Postdoctoral experience in Breast cancer research. Current: Clinical Genomics and Pharmacogenomics.

Organizations
Academic

Publications
Cancer Cell International, Cancer Epidemiology Biomarkers and Prevention, Breast cancer research and treatment, Indian Journal of Pediatrics, BMC Proceedings, Pharmacogenetics and Genomics, Human Molecular Genetics, Frontiers in Genetics, Cancer Biomarkers.

Education/Credentials
PhD Biomedical Genetics

Awards and Honors
University Grants Commission Award for pursuing PhD level research (India); Travel awards to attend conferences.

Past/Present Clients
Post doctoral experience Cancer research, molecular epidemiology Current: Clininical Genomics and Pharmacogenomics

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