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Genetics/Gene Regulation


Dear Natarajan
I want to know if I remove a houskeeping gene that is essential for general cell metabolism,from euchromatin to a region of hetrochromatin, what would be the likely effect on the cell?

2- we have fewer gene regulators than genes in the cell. so how specific gene activate or regulate? could one regulatory gene activates more than on gene? so how it can discriminate between them? would you please explain about this?

Hi Alhan,

If you moved a gene to heterochromatic region, the most likely effect is that it wont express. These are regions tightly bound bound proteins and not available for transcriptions. Thus the cell may die, if this gene is a housekeeping one.

Gene regulation occurs at many levels and is very complex. A single regulator can act on many genes, Besides, regulation can occur at protein level for some genes by protein modification. Regulators may discriminate based on certain consensus sequences and thus know to identify several genes based on a specific characteristic.



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Thanemozhi Natarajan


Answers in Genetics, genomics, cytogenetics of syndromes, congenital anomalies, cancer, clinical genomics and interpretation of omics data.


More than 10 years. Doctoral research thesis on Congenital anomalies and cytogenetics, Recurrent reproductive failure and chromosomal abnormalities. Postdoctoral experience in Breast cancer research. Current: Clinical Genomics and Pharmacogenomics.


Cancer Cell International, Cancer Epidemiology Biomarkers and Prevention, Breast cancer research and treatment, Indian Journal of Pediatrics, BMC Proceedings, Pharmacogenetics and Genomics, Human Molecular Genetics, Frontiers in Genetics, Cancer Biomarkers.

PhD Biomedical Genetics

Awards and Honors
University Grants Commission Award for pursuing PhD level research (India); Travel awards to attend conferences.

Past/Present Clients
Post doctoral experience Cancer research, molecular epidemiology Current: Clininical Genomics and Pharmacogenomics

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