Heart & Cardiology/brugada syndrome


i took a physical for a job and an abnormal ekg came up and they said  i have possible brugada syndrome.It is terryfing what they said about nocturnal sudden death is there a treatement for this and how does one know for sure?

Hello Nes,

If you've not fainted and if there is no family history of fainting or sudden unexplained death, you probably don't have Brugada.  There is treatment.  To know for sure, see below.

Medical knowledge changes very fast. You may consider contacting us directly at the enclosed email before taking any decisions or making recommendations, or for the purpose to sent blood samples for genetic studies.

The following strategy is recommended at present:

1.- From each individual seen because of the diagnosis or suspicion of Brugada syndrome take a medical history with special attention to symptoms that may suggest arrhythmias like syncope, presyncope, dizziness, palpitations. Special attention must also be given to a family history of unexplained syncope, sudden death and unexplained traumatic deaths like car accidents that may result from loss of consciousness. Do not accept a diagnosis of the causes of sudden death or syncope unless proven. In 50% of the cases of sudden death in families with Brugada syndrome the cause of sudden death is Brugada syndrome, but in the other half the cause is a myocardial infarction or is unclear.

2.- Physical examination will usually be normal, but it should be carefully done to exclude any condition that may simulate Brugada syndrome.

3.- Record a 12-lead resting electrocardiogram and an electrocardiogram after the administration of either:

a.- ajmaline 1mg/kg body weight iv in 5 minutes, or

b.- flecainide 2 mg/Kg body weight iv in 10 minutes, or

c.- procainamide, 10 mg/kg body weight iv in 10 min.

These tests should be performed in an environment with facilities for CPR because in 0.5% of tests the patient may develop ventricular fibrillation. Ajmaline is the preferred drug because of the very short half-life. If necessary, consider approval of the test by your local ethical committee before performing it.

A pharmacologic test is considered positive if an additional 1 mm ST segment elevation appears in leads V1, V2 and V3. The ST segment elevation is measured 0.08 s after the J wave.

4.- All positive individuals should undergo programmed ventricular stimulation to assess inducibility of ventricular arrhythmias and to measure the conduction intervals (the H-V interval is frequently prolonged in Brugada syndrome). Programmed ventricular stimulation should at least include two different pacing cycle lengths from the right ventricular apex and at least two ventricular premature beats.

Please write back if this doesn’t answer all your questions.

David Richardson

Heart & Cardiology

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David Richardson


Adult heart function and disease. Not very good about children lesss than 12. Hypertension is o.k. Heart rhythm a special interest.


Certified in cardiology by the American Board of Internal Medicine. Was chairman of division of cardiology at the Medical College of Virginia. Am now mostly retired.

Fellow of American Heart Association and American College of Cardiology and member of American Physiological Society..

Circulation, American Heart Journal, Hypertension.

M.D. from Harvard Medical School. Residency training at Yale Uhniversity School of Medicine and Medical College of Virginia.

Awards and Honors
Gold Heartt Award from American Heart Association in 1995.

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