Hematology/Blood work


QUESTION: I am taking plaquenil for UCTD. My sed rate and C-reactive protein are now normal. My homogeneous ANA went from 1/320 prior to taking plaquenil to 1/160. My SS DNA, complement 4 continue to be elevated. The past month. I have had joint/muscle pain throughout the day without sweeling or warmth. At times, when driving, the muscles in my thighs feel fatigued and achy. Could this mean that I am moving from UCTD to a mre defined disease?

Yes, development of new symptoms may give us more clear picture. If symptoms co-relate to a particular connective tissue disease then we can say UCTD is turning into a more defined connective tissue disease! If full symptoms do not develop, then we have to consider it as UCTD only. Other than joint pains you have no other symptoms? Is it only one joint or multiple joints?

Thanking you!

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QUESTION: I have intermittent periods when my entire body is achy feeling. I have had disequilibrium when I stand and sometimes when I move my head side to side either sitting or laying down the past 2 months. The disequilibrium lasts 5 or 10 seconds.  A schrimers test showed slightly reduced tear production. My mouth is often dry but I had a negative salivary gland biopsy. I get frequent sinus infections.  Often when scoped, the ENT notes significant sinus inflammation. I tend to produce copious amounts of chronic thick, sticky post nasal drip. Two years ago, I had a sudden large pericardial effusion. A liter of blood was drained but came back and I was in tamponade necessitating a pericardial window. The biopsy showed chronic and accute inflammation.  Despite having pericarditis, my heart was undamaged but I have tachycardia and palpitations since. Verapimal is controling the symptoms. I developed heat intolerance 2 years ago, have fatigue, have itchy skin and get intermittent rashes on my arms and back.

You have UCTD with secondary sjogren's syndrome. Recurrent sinusitis is a symptom of sjogren's. And I think I previously answered your question, by that I remember Your UCTD is more likely Lupus. It may take some time to fully develop.

Thanking you!


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Dr.Shrinidhi Kulkarni


I can answer all questions related to hematology. RBC, WBC, Platelet and blood forming organs etc and related questions. hematology also includes blood proteins, hemoglobin and disorders related to clotting abnormalities. So questions about all aspects of hematology are welcome!


Working as a Doctor in Primary Health care Centre.

KIMS Banglore

MBBS, Internship in Internal Medicine

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