I am a 60 year old female. Immunoglobulin E, Total 3215
I have been allergy tested 5 times with negative results. Sed rate, C reactive protein, compliment 4, IGE have been elevated. Homogeneous ANA is intermittently elevated. I have chronic sinus inflammation intermittent rashes and well as chronic inflammation of the pericardium. I have significant osteoarthritis in my spine, knees and TMJ. What could be causing these symptoms? Testing for lupus,Sjogrens, rheumatoid arthritis and vasculitis have been negative.
My suggestion is you meet a gynecologist and get your ovaries scanned once. What was the age when you menopaused? Elevated IgE with high ESR, C4 etc indicate problems with ovary. But still I recommend you repeating the other tests like ANA and screening for connective tissue disorders after an year. Sometimes when a person has mixed connective tissue disorder(MCTD), during initial phase the symptoms are overlapping and tests are non-conclusive. As the disease progresses it takes a definitive form and one of the connective tissue disorder becomes predominant. So better to wait and keep screening. Hope I have cleared your doubts, if you have any further questions you can feel free to share your thoughts.