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Infertility/Fertility/Beta 3 integrin testing


Hi Dr. Ramirez,

What are your thoughts on beta -3 integrin testing for unexplained infertility. I've read that treatment for those lacking the protein is either 3 months of depot lupron or letrozole. We have done all the testing except a lap and everything had tested great. I just turned 35 and my husband is 34. We have had one failed IVF cycle where we transferred two 5 day blasts (grade A and B) . We have one grade A 6 day blast frozen. We are getting ready for a second fresh cycle and if that fails I would like to do this test before transferring any frozen embryos.

Hello Sunny from the U.S. (Maryland),

I don't do b-integrin testing for the simple reason that if it is negative, then additional progesterone is the treatment of choice.  Because progesterone is fairly innocuous, I choose to treat all my patients with extra progesterone (injectable and vaginal).

Good Luck,

Dr. Edward J. Ramirez, M.D., FACOG
Executive Medical Director
The Fertility and Gynecology Center
Monterey Bay IVF Program

Monterey, California, U.S.A.

for additional information check out my blog at check me out on twitter with me at @montereybayivf and facebook @montereybayivf.  Skype and internet comprehensive consultations now available via my website for those who want a more extensive evaluation that this site can accommodate.


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Edward Joseph Ramirez, MD, FACOG


I am a specialist in infertility and advanced gynecological care. I can answer questions about infertility, gynecology related ills, menopause...virtually anything that affects women's health. PLEASE tell me where you are writing from as I am always interested.


I have been practicing as an Ob/Gyn and Infertility Specialist for over 23 years. Gynecology, advanced laparoscopic surgery, basic infertility, IUI's, IVF, reproductive surgery, and ovulation induction are all areas of my expertise. I am Board Certified. I have been doing In Vitro Fertilization in my clinic for 19 years.

American College of OB/GYN, American Board of Obstetrics and Gynecology, American Society of Reproductive Medicine, California Medical Association, American Association of Gynecologic Laparoscopists, Fellow of The American College of Obstetricians & Gynecologists

American Journal of Obstetrics and Gynecology, Wall Street Journal, Monterey Herald, SERMO, Women's Health and Fertility Blog

Medical Degree from Stanford University, Residency at Tripler Army Medical Center, Reproductive Training at Pacific Fertility Center, San Francisco

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