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Infertility/Fertility/chemical pregnancy on Buserilin


Dear Dr. Ramirez,

I am from the UK. I have asked you a question some time ago.Thank you for being generous with your time and advice.

I was on a long ivf protocol with downregulation on Buserilin . My clinic allowed us to try to conceive on the same cycle as the treatment( with buserilin being started on day 21 of the cycle)    On day 10 of Buserilin treatment, I had a positive pregnancy test and I was asked to stop Buserilin. However, this ended in a chemical pregnancy 2 days later.

My question is what your advice would be on whether trying to conceive naturally whilst on Buserilin as I will be restarting the long protocol again. I am asking this question as there is contradictory advice in the internet.

Your advice would be much appreciated.

Thank you in advance.

Hello R from the U.K.,

Buserillin is a GnRH agonist, similar to Lupron.  I'm not sure exactly what the purpose of the medication was in your clinic's protocol. It is the first time I've heard of it used in that way.

I'm not sure that it would have any benefit in a natural cycle, but that is more because of my experience with using Lupron.  I would presume that without ovarian stimulation, ovulation would not occur (as in the long protocol), but as mentioned, I'm not sure what the thinking is regarding using it from CD#21, so I'm not sure I can advise you on this.

Good Luck,

Dr. Edward J. Ramirez, M.D., FACOG
Executive Medical Director
The Fertility and Gynecology Center
Monterey Bay IVF Program

Monterey, California, U.S.A.

for additional information check out my blog at check me out on twitter with me at @montereybayivf and facebook @montereybayivf.  Skype and internet comprehensive consultations now available via my website for those who want a more extensive evaluation that this site can accommodate.


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Edward Joseph Ramirez, MD, FACOG


I am a specialist in infertility and advanced gynecological care. I can answer questions about infertility, gynecology related ills, menopause...virtually anything that affects women's health. PLEASE tell me where you are writing from as I am always interested.


I have been practicing as an Ob/Gyn and Infertility Specialist for over 23 years. Gynecology, advanced laparoscopic surgery, basic infertility, IUI's, IVF, reproductive surgery, and ovulation induction are all areas of my expertise. I am Board Certified. I have been doing In Vitro Fertilization in my clinic for 19 years.

American College of OB/GYN, American Board of Obstetrics and Gynecology, American Society of Reproductive Medicine, California Medical Association, American Association of Gynecologic Laparoscopists, Fellow of The American College of Obstetricians & Gynecologists

American Journal of Obstetrics and Gynecology, Wall Street Journal, Monterey Herald, SERMO, Women's Health and Fertility Blog

Medical Degree from Stanford University, Residency at Tripler Army Medical Center, Reproductive Training at Pacific Fertility Center, San Francisco

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