Infertility/Fertility/Priming medications for FET shorten period?
Dear Doctor Ramirez,
I'm 43 and have just started FET cycle using donor eggs. Starting day 4 of my period, I'm on Premarin 0.625mg (one tablet 3 times a day) and ASA 100mg once at evening. On day 12 of my cycle, an ultrasound would be performed to see the thickness of my endometrial lining and I would then start progesterone tablets. I understand from reading your blogs and Q&A that you would advice estrogen and progesterone suppositories instead of oral tablets. But at the current clinic, the doctor only gave me oral forms of the meds.
My period regularly runs for 7 days, trailing off the last couple of days. But after I started Premarin and ASA, my period came to a stop on day 5. Is this whats expected? Does this mean the old lining hasn't been completely shed off? Would the shortened period affect my endometrial lining for the upcoming FET and implantation?
Thanks very much,
Hello Sue from Hong Kong,
In FET cycles, the only requirement is to develop then ready the endometrial lining for implantation. This is done with estrogen and then progesterone. Clinics use different protocols for all aspects of IVF. Studies have shown vaginal or injectable hormones to be the best in getting to the uterus (because it goes there first after being absorbed as opposed to going through the digestive system and liver first when taken orally), but as long as the uterine lining develops properly, oral certainly can work. The key is to have an adequate endometrial lining. The progesterone, which is started based on when the transfer is supposed to occur, changes the architecture of the lining to its final receptive state. That timing is critical.
In terms of the early stoppage of your period, that is to be expected. The rapidly rising estrogen level would create a new lining, thereby shielding the blood vessels exposed by the period, and stop the bleeding. It is not anything you need to worry about. It will not affect the timing of the lining. FET cycles are completely programmed all the way to the date of transfer.
Dr. Edward J. Ramirez, M.D., FACOG
Executive Medical Director
The Fertility and Gynecology Center
Monterey Bay IVF Program
Monterey, California, U.S.A.
for additional information check out my blog at http://womenshealthandfertility.blogspot.com
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