AboutScott Roseff, MD, FACOG Expertise I can answer questions relating to ALL aspects of female infertility.
Experience I am Board Certified in Reproductive Endocrinology/Infertility.
Organizations Medical Advisory Board, Serono Labs, Inc.
Speaker's Bureau, TAP Pharmaceuticals, Inc.
The American Society for Reproductive Medicine
American Association of Gynecologic Laparoscopists
The International Society for Gynecologic Endoscopy
The Society of Laparoendoscopic Surgeons
The International Federation of Gynaecologic Endoscopists
U.S. International Foundation for Studies in Human Reproduction, Inc.
The Endometriosis Association
Fellow, The American College of Obstetricians & Gynecologists
American Medical Association
The Academy of Medicine of NJ
NJ Obstetrical & Gynecological Society
The NY Reproductive Medicine Society (Steering Committee)
The Society of Reproductive Endocrinologists
Resolve - National Chapter
Resolve - New Jersey - Executive Board
Publications Kettel LM, Roseff SJ, Berga SL, Mortola JF, Yen SSC. Hypothalamic-pituitary-ovarian response to clomiphene citrate in women with polycystic ovary syndrome. Fertil Steril. 1993;59:532-8.
Fischer UG, Wood SH, Bruhn J, Roseff SJ, Mortola JF, Rivier JE, Yen SSC. Effect of human corticotropin-releasing hormone on gonadotropin secretion in cycling and postmenopausal women. Fertil Steril. 1992;58:1108-12.
Kettel LM, Roseff SJ, Bangah M, Burger HG, Yen SSC. Circulating levels of inhibin in pregnant women at term: simultaneous disappearance with oestradiol and progesterone after delivery. Clin Endocrinol. 1991;34:19-23.
Kettel LM, Roseff SJ, Chiu TC, Bangah ML, Vale W, Rivier J, Burger HG, Yen SSC. Follicular arrest during the midfollicular phase of the menstrual cycle: a gonadotropin-releasing hormone antagonist imposed follicular-follicular transition. J Clin Endocrinol Metab. 1991;73:644-9.
Roseff SJ, Kettel LM, Ulmann A, Bangah ML, Rivier J, Burger HG, Baulieu E, Vale W, Yen SSC. Accelerated dissolution of luteal-endometrial integrity by the administration of antagonists of gonadotropin-releasing hormone and progesterone to late-luteal phase women. Fertil Steril. 1990;54:805-10.
Roseff SJ, Murphy AA. Laparoscopy in the diagnosis and therapy of chronic pelvic pain. In Clinical Obstetrics and Gynecology. JB Lippincott Co., Philadelphia. 1990.
Roseff SJ, Murphy AA. Pelviscopy. In Manual of Endoscopy, by the American Association of Gynecologic Laparoscopists, Edited by DC Martin, GL Holtz, M Wenof. Santa Fe Springs. 1989.
Roseff SJ, Bangah M, Kettel LM, Vale W, Rivier J, Burger HG, Yen SSC. Dynamic changes in circulating inhibin levels during the luteal-follicular transition of the human menstrual cycle. J Clin Endocrinol Metab. 1989;69:1033-9.
Roseff SJ, Bernard JM. Seasonal changes in carbohydrate levels in tissues of Carex lacustris. Can. J. Bot. 1979; 57:2140-44.
Education/Credentials Postgraduate Fellowship training in Reproductive Endocrinology & Infertility was done at The University of California, San Diego, School of Medicine.
Awards and Honors Mellon Fellow in Reproductive Endocrinology and Infertility, 1988, awarded for academic excellence in the Reproductive Sciences, for research efforts aimed at development of novel contraceptives.
Wyeth Service Award for Physician Education and Training in Norplant Contraceptive Implants.
Certificates of Service and Appreciation from Our Lady of Mercy Medical Clinic, Guadalajara, Jalisco, México, 1978-1982.
Question Hi Dr. Roseff:
I have a 10 yr. eating disorder history now under control for 5 yrs---the cause of my infertility.
I took clomid 1 yr. ago & at the highest dosage it did not appear to make me ovulate but to my and my dr's surprise, that month I did become pregnant and gave birth to a healthy girl.
I was close to gonadotrophins injections (FSH). Next month we are trying clomid again but I may need injection treatment.
My first question has to do with Gonadotrophins and Creutzfeldt Jakob Disease (CJD). I read that CJD is the human disease name of Spongiform encephalopathy (BSE) disease in cattle known as mad cow disease.
Recently, a person from our small community died of what they believe may be a form of CJD now found in deer. I'm from the Midwest and recently some of the deer came down with "Chronic Wasting Disease". The health professionals/news media aren't discussing the relation between CJD and the wasting disease but the family members of the person who died from infected deer meat have been informing our community.
I read articles the family members pointed us to and to my SURPRISE..... it said CJD/death has been proven to be caused by human pituitary gland hormone injections. It appears from my research that the United States hasn't really touched this topic.
Have you ever heard of this? Do you know if the problem still exists or if it was back in the 1980's and early 1990's? Do you know if there has been success filtering the CJD agent out of the pituitary hormones being injected into infertile women? I haven't found any statistics on how common or rare it is that it's found in these injections. I'm hoping it is so uncommon that I should be worryfree to go ahead with injection treatment if needed.
Thanks for your attention to this long question. It still amazes me that I came upon this issue while reading an article on CDJ in humans being a form of mad cow disease and the chances that this may be showing up in deer in the Midwest.
Shari
Answer Hi Shari,
Injectable fertility drugs used to be manufactured from human pituitary extracts, but since that WAS proven to be linked to CJD, that process was abandoned many years ago.
The injectable fertility drugs today are made from either postmenopausal women's urine or via recombinant technology. You should read more about this at one of the fertility drug company's websites at http://www.seronousa.com/fertility/frame_treat.html?hormonal.html
I hope this is helpful information for you!
Dr. Roseff, Director W.E. C.A.R.E.
Visit us at www.reproendo.com
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Since I don't know your entire history and haven't examined you, any medical information given to you may be incomplete or inaccurate. Therefore, Dr. Roseff and the W.E. C.A.R.E. staff can not be responsible for any actions taken or not due to the information contained within these communications. These communications are for educational and informational purposes only, and should never be used to replace the information and care rendered by your own doctor. No part of this message may be reproduced, printed, or posted anywhere without the express written authorization of Dr. Roseff.
