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Lupus/High anti dsdna level


QUESTION: Hi..I've been diagnosed with lupus since 2012. Most recently my blood work showed ana of 1: 640, anti dsdna of 493 (norm for my lab is <30). This number has been rising for the past 7 mos, but my complement levels are normal. My rheumatologist says this is "odd", but still insists I have lupus. I've had almost all the symptoms over the past 4 years so I want to believe him...but he got me nervous about the normal complements.

Are there any other diseases that would have such a HIGH anti dsdna level?? I know there are some other than SLE that have a low abnormal anti dsdna

ANSWER: The anti DsDna can elevate prior to a flare up in lupus. This antibody is pretty specific for lupus. Typically in SLE the complement levels go low, but your body didn't read any text book so your diagnosis should be based off clinical signs and symptoms and paired with lab testing.

Other reasons anti DsDna can elevate:

Anti-dsDNA is sometimes present with diseases such as chronic hepatitis, primary biliary cirrhosis, and infectious mononucleosis. It may also be seen in those taking drugs such as procainamide and hydralazine. It is not usually tested or monitored under these conditions.

Dr. Kalli Prater, D.C.

---------- FOLLOW-UP ----------

QUESTION: Thank you so much for the quick response! I just have one more question . I read on google (probably a dumb move) that lymphoma will make the dsdna level VERY high, like mine is. Do you happen to know if that is true? My mom had Hodgkins lymphoma 15 years ago so I guess what i read is making me nervous!

Google- not your best friend at the moment :)

Your signs and symptoms need to be clinically correlated with your lab findings, lab findings alone mean very little. All too often people ask me what's wrong based on labs alone and it just can't be done. If you have concerns of this, I would recommend bringing it up to your Doctor and re-state your family history with your doctor. They should already know this, but for your own peace of mind I would bring it up and ask if there's a correlation with him.

Hopefully this helps.  


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Dr. Kalli Prater


I can answer questions about nutrition for autoimmune diseases, especially those with Lupus. Questions about when to seek medical help, when and what alternative therapies are recommended. Alternative therapy effectiveness compared to traditional medical treatment. Also answering questions about lab testing for Lupus, functional lab interpretations and how to turn around your blood work.


Currently treat many autoimmune patients with my biggest success in Lupus through dietary modification. With a reversal of lab work and off all medication in less than 1 years time, my interest is in giving back the quality of life to people with Lupus and autoimmune disease.

America Chiropractic Association

I am a Doctor of Chiropractic with almost 300 post graduate hours in internal medicine and diagnosis of internal disorders. By focusing on proper diagnosis, treatment with diet and nutrition as a complement to traditional medical intervention and management quality of life is attainable.

Awards and Honors
Recognized as a leader in the field of Chiropractic by the International Association of Health Care Professionals 2014

Past/Present Clients
Currently oversee the treatment of a patient with lupus who has changed her diet and has mad drastic improvements in health including no longer taking medication for her condition. This patient is currently preparing for a home birth with her first non-risk pregnancy and her 4th child. The patient was able to stay out of the hospital for common colds and allergies when previously she would spend 2-3 days for any issue in the ER trying to manage inflammation and flare ups.

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