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Mice/Mice dosage


I have a thesis paper regarding about the renoprotective potential of Saccharum spontaneum Linn. but the toxicity study was conducted in rats. Can the dosage that was used in rats be used in mice? If yes, how? I would really appreciate an immediate answer for this for it is due this month. Thank you very much.

Hi Aila,

One thing to understand about animal models is that different species will metabolize and react to things differently.  Something that may be toxic at a certain level or by a certain mode of administration for a rat may affect a mouse differently, even though they are both rodents.  Another thing to consider is that a rat weighs significantly more than a mouse, so chances are the dosages used to determine toxicity will need to be adjusted by weight.  Hopefully the study you have gave dosages in amount per unit of weight, or the weight of dosed animals, so it should be easy to derive analogous dosages for lower weights, provided other factors like the metabolism are similar enough.  That'd be a good starting point, in my opinion.  I'm sorry, I don't know what you mean when you ask, "how?"

Short answer - no, dose levels in a rat toxicity study will not correspond directly to mice.  Also, while I understand the urgency of your paper, I'm not exactly a citable source.  Your best bet is to hit the papers and see what you can dig up.

Best of luck!


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