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Nanotechnology/polymeric nanoparticle for eye


dear sir

i am doing project on polymeric nanoparticles for ocular delivery. my  question is how to fix the dose  of antibacterial drugs .how to select the ratio of drug and polymer ratio..i hope that you will answer for my questions.

example ciprofloxacin or norfloxacin .....

thank u sir

Generally, from entrapment efficiency and drug release we calculate how much drug will be available in how much milligram of nano particles.

Then we use that amount of nano particles in 2 ml of solvent.

You should keep same concentration of drug in nano particle suspension as its in marketed formulation for comparison.  


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Himanshu Gupta


I can answer questions related to nanoparticles drug formulations especially polymeric nanoparticles and their evaluations. I can reply to other drug formulation related scientific queries and publication. Experienced Formulation Scientist with doctoral degree in Pharmaceutical Sciences. Significantly contributed for advancement of projects at various stages of drug product development cycle from conceptualization to proof-of-concept studies in animals that resulted in invention disclosures. Efficient and diligent team worker with proven track record of being problem solving and innovative


I have experience in PLGA and other polymer based nanoparticles for ocular delivery. Specialties: Formulation and product development (ocular, transdermal, skin care), Polymeric nanoparticles, in situ gel, pHEMA gel and emulsion based formulation development, excipient interaction and stability study, In vitro and in vivo evaluation of drug products, ocular/skin irritation studies, radiolabeling of small drug molecules, preclinical drug evaluation in rabbits and rats, Franz diffusion cell for skin/corneal permeation studies, SOP and report writing, documentation for regulatory submissions, analytical techniques such as HPLC, UV-Vis, DSC , viscometer, osmometer, DLS, SEM, ERG (Electro retinography), IR camera. Hands on instrument experience for formulation development i.e. high pressure homogenizer, lyophilizer, ultra sonicator, ultra centrifuge, autoclave, gamma sterilization, cold compression etc.

Organization of Pharmaceutical Unity with BioAllied Sciences (OPUBS) Journal of Pharmacy and Bioallied Sciences Chronicles of Young Scientists

Drug DeliveryDecember 8, 2007 Drug Delivery 14(8) 2007, 507-515. AAPS Pharm. Sci.10(2) 2009, 540-546. Journal of Chromatographic ScienceJanuary 7, 2010 Authors: Himanshu Gupta Journal of Chromatographic Science 48 (1) 2010, 1-6. A Single RP-UPLC method for quantification of Levofloxacin in aqueous humour and pharmaceutical dosage forms Journal of chromatographic ScienceJune 9, 2010 Authors: Himanshu Gupta Journal of chromatographic Science 48, 2010: 484-490. Sparfloxacin loaded PLGA nanoparticles for sustained ocular drug delivery Nanomedicine: Nanotechnology, Biology, and MedicineAugust 7, 2010 Authors: Himanshu Gupta 22. Himanshu Gupta, Nanomedicine: Nanotechnology, Biology, and Medicine 6(2) 2010, 324-333. Journal of Drug TargetingNovember 5, 2010 Authors: Himanshu Gupta Himanshu Gupta, T. Velpandian, Sanyog jain. Ion- and pH- activated novel in-situ gel system for sustained ocular drug delivery. Journal of Drug Targeting 18(7) 2010, 499-505. Journal of Pharmacy and Bioallied SciencesFebruary 5, 2010 Himanshu Gupta, Journal of Pharmacy and Bioallied Sciences 2(1) 2010: 2-7 Journal of Drug TargetingFebruary 5, 2011 Himanshu Gupta, Journal of Drug Targeting (Accepted) Recent Patents on Anti-Infective Drug DiscoveryJuly 7, 2009 Recent Patents on Anti-Infective Drug Discovery 4 (3) 2009, 154-163. Journal of Applied SpectroscopyDecember 9, 2009 Journal of Applied Spectroscopy 76 (6) 2009, 876-882. Biodegradable biomaterial Recent patent on biomedical engineering2010 Authors: Himanshu Gupta Himanshu Gupta,Recent patent on biomedical engineering 3(1) 2010. 30-40. European Journal of Medicinal Chemistry2011 Recent Patents in Drug Delivery and FormulationMarch 2011 Recent Pat Drug Deliv Formul.January 2010 Recent Patents in Drug Delivery and Formulation 4 (1) 2010, 82-89. Recent Pat Drug Deliv Formul.June 2009 Drug Discovery TodayJanuary 30, 2012 Crit Rev Ther Drug Carrier Syst.February 2012

Diploma in Pharmacy Bachelor in Pharmacy Masters in Pharmacy Post Grad Diploma in Int. Business PhD in Pharmaceutics Post Doc (USA)

Awards and Honors
- Hamdard Appreciation Award 2011 - Awarded with “Dr. P. D. Sethi Annual Award 2010” - Received International travel grant from DST, Ministry of Science and Technology (Govt. of India) for 37th CRS, USA. - Invited to Moderate “Nanotechnology I” session in 37th Annual Meeting and Exposition of the Control Release Society, Portland, Oregon, USA 10-14 July 2010 - Awarded “Budding Nanotechnologist Award” (Young Scientist Award) in DST (Ministry of Science and Technology, Govt. of India) sponsored 2nd Summer School on Nanotechnology in Advanced Drug Delivery, NIPER, Chandigarh, 2009. - Received SRF fellowship of Central Council of Scientific and Industrial Research (CSIR), Govt. Of India, New Delhi, India. - Awarded SRF fellowship of Indian Council of Medical Research (ICMR), Govt. of India, India. - Conference Grant from Society of Nuclear Medicine (India) - Organized planary lectures and symposium with scientific committee in 60th IPC. - Conference Grant from IOMC

Past/Present Clients
Editor African Journal of Pharmacy and Pharmacology Science and Technology June 2009 – present (3 years 1 month) Editorial Board Member Recent patents in Drug Delivery & Formulation Science and Technology July 2010 – present (2 years) Editorial Board Member Recent patents on nanomedicine Education July 2011 – present (1 year) Conference student board member 3rd International Online medical conference (IOMC) Education June 2010 – October 2010 (5 months) Reviewer Journal of ocular pharmacology and therapeutics Education Asst. Editor Journal of Pharmacy and Bioallied Sciences Science and Technology December 2011 – present (7 months) To help in editorial process in the scientific articles. Asst. Editor Chronicles of Young Scientists Science and Technology January 2010 – present (2 years 6 months) Editorial process Managing Editor Journal of Pharmacy and Bioallied Sciences Science and Technology December 2009 – December 2011 (2 years 1 month)

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