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Nephrology/protein in urine


I am diagnosed with undifferentiated connective tissue disease. My c-reative protein, sed rate, IGG, complements 4+5 have been elevated several times over the past 18 months.  My ss anti dna was elevated twice and homogeneous ANA 1:320 one time.  My symptoms include frequent inflammation in sinus, mild to moderate constriction small airways, pericarditis, pericardial effusion(1 liter blood drained), rashes that come and go, mild brain fog, temperature dysregulation, mildly reduced tear production.  I have been taking plaquenil for the past 3 months.

Over the past 18 months, my bun/creatinine ratio has often ranged from 27-32.  I had a urinalysis in May and then again in June.  Both times, there was protein in my urine.  A repeat urinalysis done 4 days ago was normal.  I have been told that my elevated bun/creatinine was due to dehydration and not to worry.

Is it possible that the two urine samples that showed protein was due to inflammation/autoimmune illness?  Is this something to be concerned about?  Should I see a Nephrologist?

urine- protein +1
BC ratio (blood)  31

creatinine       348.3    urine
protein          29.3     
Blood          normal
bun/creatinine  27
bun/creatine  28

bun/creatinine -27

bun/creatininen  32

bun/creatinine ratio  28


I apologize for the delay in answering to your question on Allexperts.

It is quite likely that the presence of protein in your urine is due to your autoimmune disease. Please ask your primary care provider to order a 24 hour urinary albumin measurement or a spot urine albumin-creatinine ratio.

If the result shows the presence of protein in your urine, you should get a Nephrology consult.


Dr. Shah


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Dr. Shamik Shah, MD, DNB (Nephrology), ISN Fellow


I can answer all questions related to kidney diseases, hypertension, plasmapheresis and kidney transplantation. I am an Indian-Board certified Nephrologist. I was a post-Doctoral Scholar at the Division of Nephrology & Hypertension,Department of Medicine, University of California, San Diego. My area of interest is Critical care Nephrology and Acute Kidney Injury.

Please mention the units in which your lab results were reported and the normal reference range for your laboratory.

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Ten years as a Critical Care & Transplant Nephrologist

International Society of Nephrology
Indian Society of Nephrology
Indian Medical Association
European Renal Association

- Shah SH, Cerda J. Acute Tubular Necrosis; Lerma, Edgar V., Rosner, Mitchell eds. Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation. Springer ISBN 978-1-4614-4453-4, pp. 191-198
- Shah SH, Cerda J. Management of Acute Kidney Injury; Lerma, Edgar V., Rosner, Mitchell eds. Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation. Springer ISBN 978-1-4614-4453-4
- Cerda J, Tolwani A, Shah SH, Ronco C. Continuous Renal Replacement Therapies in Modeling and Control of Dialysis Systems edited by Azar AT, Springer-Verlag, Heidelberg, Germany (In Press)
- Shah SH, Cerda J, Kellum JA. Acute Kidney Injury in Special Circumstances. John Kellum, Jorge Cerda, eds. Renal and Metabolic Disorders, Oxford University Press (In press)
- Shah SH, Mehta RL. “Anticoagulation in CRRT: Is Citrate better?”; Vineet Nayyar Ed. Critical Care Update 2009, Jaypee Brothers (In press)
- Shah SH, Mehta RL. “Non-dialytic management of acute kidney disease”; Evidence based Nephrology, BMJ, (In press)
- Shah SH, Mehta RL. “Epidemiology of Community-acquired AKI”; Ronco C, Bellomo R, Kellum J Eds. Critical Care Nephrology, Saunders. ISBN 1-4160-4252-0
- Abdeen O, Shah SH, Mehta RL; “Dialysis therapies in the surgical intensive care unit”; William Wilson, Christopher Grande, David Hoyt Eds. Trauma: Resuscitation, Anesthesia, and Critical Care, Informa Healthcare, NY 2007. ISBN 0-8247-2920-X
- Shah SH, Mehta RL. Acute kidney injury in critical care: time for a paradigm shift? Curr Opin Nephrol Hypertens. 2006 Nov;15(6):561-5.
- Shah, SH, Soroko S, Lischer E, Mehta RL. Delivered vs. Prescribed dose of Dialysis in Hospitalized Patients: Results of an Audit. J Am Soc Nephrol 17(Abstracts Issue): 2006, 107A.
- Shah SH et al “Biochemical Nutritional Parameters in Non-vegetarian and Vegetarian CAPD patients” Perit Dial Int 2001; 21 Suppl 2: S1-182

MBBS, MD (Internal Medicine), Diplomate of National board (Nephrology), ISN Fellow

Awards and Honors
Educational Ambassador of the International Society of Nephrology 2010
Fellowship of the International Society of Nephrology 2005.
Young Investigator Award by the International Society of Peritoneal Dialysis 2001

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