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Nephrology/Elevated Creatinine



My husband, 37 yrs old, not overweight, exercises regularly. He is not diabetic and does not have high blood pressure. He was diagnosed with a pituitary tumor 15 yrs ago. so he gets full blood work every 6 months. Nothing has changed in his diet or his medications.

His last lab result showed his Creatinine elevated at 1.46 (range 0.60-1.35)

BUN was 18 (7-25)
eGFR was 61 (> OR = 60)
BUN/Creatinine ratio was 12 (6-22)

All other results were normal also. His previous lab results showed his creatinine between 1.20 and 1.28

Can you explain why his creatinine would be elevated?  Should we be worried there is something wrong with his kidneys?

Thank you in advance for your help.


Thanks for asking my opinion on Allexperts.

I would not worry too much about one reading of elevated S.Creatinine. Please ask your doctor to repeat the test. If in doubt, get a 24 hour creatinine clearance.

To find the cause of elevated S.Creatinine, a detailed history, physical examination, other lab tests and imaging of the urinary tract are required. Unfortunately, I cannot do this over the internet.


Dr. Shah

---------- FOLLOW-UP ----------

QUESTION: Thank you for your response.

He was taking Advil twice a day for about 2 months for some neck pain.  Could this have caused his creatinine to rise?
Have you had any patients with elevated creatinine and then just a repeat test showed it within range again without an underlying cause?

Thank you in advance.

Thanks for following up with me, Rose.

Advil twice a day for 2 months can definitely cause a rise in S. Creatinine. Please ask him to stop self-medicating immediately and consult a doctor. Advil belongs to a class of drugs known as NSAIDs - Non Steroidal Anti Inflammatory Drugs and kidney failure is a very serious side effect of these drugs.


Dr. Shah


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Dr. Shamik Shah, MD, DNB (Nephrology), ISN Fellow


I can answer all questions related to kidney diseases, hypertension, plasmapheresis and kidney transplantation. I am an Indian-Board certified Nephrologist. I was a post-Doctoral Scholar at the Division of Nephrology & Hypertension,Department of Medicine, University of California, San Diego. My area of interest is Critical care Nephrology and Acute Kidney Injury.

Please mention the units in which your lab results were reported and the normal reference range for your laboratory.

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Ten years as a Critical Care & Transplant Nephrologist

International Society of Nephrology
Indian Society of Nephrology
Indian Medical Association
European Renal Association

- Shah SH, Cerda J. Acute Tubular Necrosis; Lerma, Edgar V., Rosner, Mitchell eds. Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation. Springer ISBN 978-1-4614-4453-4, pp. 191-198
- Shah SH, Cerda J. Management of Acute Kidney Injury; Lerma, Edgar V., Rosner, Mitchell eds. Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation. Springer ISBN 978-1-4614-4453-4
- Cerda J, Tolwani A, Shah SH, Ronco C. Continuous Renal Replacement Therapies in Modeling and Control of Dialysis Systems edited by Azar AT, Springer-Verlag, Heidelberg, Germany (In Press)
- Shah SH, Cerda J, Kellum JA. Acute Kidney Injury in Special Circumstances. John Kellum, Jorge Cerda, eds. Renal and Metabolic Disorders, Oxford University Press (In press)
- Shah SH, Mehta RL. “Anticoagulation in CRRT: Is Citrate better?”; Vineet Nayyar Ed. Critical Care Update 2009, Jaypee Brothers (In press)
- Shah SH, Mehta RL. “Non-dialytic management of acute kidney disease”; Evidence based Nephrology, BMJ, (In press)
- Shah SH, Mehta RL. “Epidemiology of Community-acquired AKI”; Ronco C, Bellomo R, Kellum J Eds. Critical Care Nephrology, Saunders. ISBN 1-4160-4252-0
- Abdeen O, Shah SH, Mehta RL; “Dialysis therapies in the surgical intensive care unit”; William Wilson, Christopher Grande, David Hoyt Eds. Trauma: Resuscitation, Anesthesia, and Critical Care, Informa Healthcare, NY 2007. ISBN 0-8247-2920-X
- Shah SH, Mehta RL. Acute kidney injury in critical care: time for a paradigm shift? Curr Opin Nephrol Hypertens. 2006 Nov;15(6):561-5.
- Shah, SH, Soroko S, Lischer E, Mehta RL. Delivered vs. Prescribed dose of Dialysis in Hospitalized Patients: Results of an Audit. J Am Soc Nephrol 17(Abstracts Issue): 2006, 107A.
- Shah SH et al “Biochemical Nutritional Parameters in Non-vegetarian and Vegetarian CAPD patients” Perit Dial Int 2001; 21 Suppl 2: S1-182

MBBS, MD (Internal Medicine), Diplomate of National board (Nephrology), ISN Fellow

Awards and Honors
Educational Ambassador of the International Society of Nephrology 2010
Fellowship of the International Society of Nephrology 2005.
Young Investigator Award by the International Society of Peritoneal Dialysis 2001

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