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Nephrology/relationship between celebrex and chemo


Dr. Shah,

My wife was diagnosed and treated fro breast cancer 7 years ago. She received doxorubicin, followed by radiation therapy (after 2X breast removal). [Initial diagnosis: multiple Stage 2B tumors, 6 months after her last mammogram was clear. Genetic testing showed no evidence of genetic issues with her or my 2 daughters.] She has been treated with Celebrex by her doctor for over 7 years to alleviate the symptoms of fibromyalgia. Her most recent blood test, which is done quarterly by her oncologist, had a creatine value of 1.3, down from her "typical" 1.4, done 3 months ago. Her fibromyalgia doctor saw the results, as well as the historical pattern, and told her to immediately seek out a nephrologist. Based on this information, is there a direct relationship between long term celebrex use (dosage = 200 mg/day) and renal issues? Follow-up question,is there any relationship between the combination of celebrex and doxorubicin therapy (either in the literature or primate/early stage studies?.) Thanks.


Thanks for asking my opinion on Allexperts.

Celebrex belongs to a class of drugs known as NSAIDs (Non Steroidal Anti Inflammatory Drugs). It is well known that long-term use of NSAIDs can lead to kidney dysfunction. You have not mentioned the normal reference range of S. Creatinine for your wife's lab. I presume that the upper limit of S. Creatinine is 1.2 mg/dl. A "usual" value of 1.4 mg/dl is not acceptable. She must be evaluated by a Nephrologist.

As far as I know, there are no significant drug interactions between Celebrex and Doxorubicin.


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Dr. Shamik Shah, MD, DNB (Nephrology), ISN Fellow


I can answer all questions related to kidney diseases, hypertension, plasmapheresis and kidney transplantation. I am an Indian-Board certified Nephrologist. I was a post-Doctoral Scholar at the Division of Nephrology & Hypertension,Department of Medicine, University of California, San Diego. My area of interest is Critical care Nephrology and Acute Kidney Injury.

Please mention the units in which your lab results were reported and the normal reference range for your laboratory.

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Ten years as a Critical Care & Transplant Nephrologist

International Society of Nephrology
Indian Society of Nephrology
Indian Medical Association
European Renal Association

- Shah SH, Cerda J. Acute Tubular Necrosis; Lerma, Edgar V., Rosner, Mitchell eds. Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation. Springer ISBN 978-1-4614-4453-4, pp. 191-198
- Shah SH, Cerda J. Management of Acute Kidney Injury; Lerma, Edgar V., Rosner, Mitchell eds. Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation. Springer ISBN 978-1-4614-4453-4
- Cerda J, Tolwani A, Shah SH, Ronco C. Continuous Renal Replacement Therapies in Modeling and Control of Dialysis Systems edited by Azar AT, Springer-Verlag, Heidelberg, Germany (In Press)
- Shah SH, Cerda J, Kellum JA. Acute Kidney Injury in Special Circumstances. John Kellum, Jorge Cerda, eds. Renal and Metabolic Disorders, Oxford University Press (In press)
- Shah SH, Mehta RL. “Anticoagulation in CRRT: Is Citrate better?”; Vineet Nayyar Ed. Critical Care Update 2009, Jaypee Brothers (In press)
- Shah SH, Mehta RL. “Non-dialytic management of acute kidney disease”; Evidence based Nephrology, BMJ, (In press)
- Shah SH, Mehta RL. “Epidemiology of Community-acquired AKI”; Ronco C, Bellomo R, Kellum J Eds. Critical Care Nephrology, Saunders. ISBN 1-4160-4252-0
- Abdeen O, Shah SH, Mehta RL; “Dialysis therapies in the surgical intensive care unit”; William Wilson, Christopher Grande, David Hoyt Eds. Trauma: Resuscitation, Anesthesia, and Critical Care, Informa Healthcare, NY 2007. ISBN 0-8247-2920-X
- Shah SH, Mehta RL. Acute kidney injury in critical care: time for a paradigm shift? Curr Opin Nephrol Hypertens. 2006 Nov;15(6):561-5.
- Shah, SH, Soroko S, Lischer E, Mehta RL. Delivered vs. Prescribed dose of Dialysis in Hospitalized Patients: Results of an Audit. J Am Soc Nephrol 17(Abstracts Issue): 2006, 107A.
- Shah SH et al “Biochemical Nutritional Parameters in Non-vegetarian and Vegetarian CAPD patients” Perit Dial Int 2001; 21 Suppl 2: S1-182

MBBS, MD (Internal Medicine), Diplomate of National board (Nephrology), ISN Fellow

Awards and Honors
Educational Ambassador of the International Society of Nephrology 2010
Fellowship of the International Society of Nephrology 2005.
Young Investigator Award by the International Society of Peritoneal Dialysis 2001

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