Oncology (General Cancer)/mantle cell lymphoma


Hi Dr. Higby, My 42 yr old nephew was just diagnosed  with stage 4 mantle cell lymphoma. They are beginning CHOP therapy. My questions are #1 What does CHOP stand for #2 What would be his life expectancy be  #3 Is 'juicing' okay or recommended? Thank you for your time.

Mantle Cell Lympoma (MCL) in advanced stages is associated with about a 50% five year survival, and very rare cure with conventional therapy.  CHOP stands for Cytoxan, Hydroxydaunomycin (adriamycin) Oncovin (vincristine) and Prednisone.  This is a standard lymphoma combination of drugs.  If your nephew doesn't have any risk factors he should be looking into much more aggressive therapy or investigational therapy.  CHOP by itself is not "state of the art" although I couldn't be sure what his doctors have in mind.  They might be starting with CHOP and if he has a good response, they might proceed with more aggressive therapy.  I would urge your nephew to get a second opinion from a nearby cancer center.  Juicing is fine, no problem.  

Oncology (General Cancer)

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Donald Higby, M.D.


I can answer almost all questions related to the treatment and natural course of most kinds of cancer, especially cancers of prostate, colon, lung and breast.


I have been a practicing medical oncologist for 36 years, and have been chief of service at a major medical center for 25 years. I've also done research in cancer treatments.

American Society of Clinical Oncology

New England Journal of Medicine American Journal of Medicine Journal of the American Society of Clinical Oncology Hematology Transfusion Medicine

MD, Stanford University Internal Medicine residency, St. Louis University School of Medicine, St. Louis, MO Medical Oncology Fellowship, Roswell Park Cancer Institute, Buffalo, NY

Awards and Honors
America's Best Physicians, last 14 years

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