AboutNeha Dahiya MD Expertise I can help patients understand their lab report results, help them with queries regarding what pretest preparation is required. How often a follow up test needs to be done. What does a particular tissue biopsy report mean in everyday English. I can explain the biopsy or cytology procedure. I can deal with Histopathology / cytology / clinical pathology and clinical chemistry queries. Helping in this manner will be my contribution to the community.
Experience I am a pathologist and director of clinical laboratory services. I have been a practicing pathologist for last 9 years in a 350 bed multi specialty hospital laboratory.
Organizations Indian association of pathologists and microbiologists.
MIAC - Member International Academy of Cytology
International association of Pathologists - indian division
Indian association of Cytology
Question I recently had a full excision of a growth on my forehead. The most recent
pathology report follows. Could you please help me understand what this
means? What may have caused this? Could it spread? I understand that I now
have to go back for further excision. On a previous punch biopsy report, the
diagnosis was: Neuroma with areas of neurofibroma with focal moderate
cytologic atypia.
Site of specimen: Forehead
Clinical Impression: Re Exc
Gross Description 22X12X6 mm exc
At the center of the specimen, there is a recent scar and a foreign body
granuloma. At the periphery and base, there is a residual proliferation of
spindle-shaped cells arranged as fascicles, predominantly around small and
medium sized blood vessels. The cells have oval to slender nuclei with fine
chromatin pattern and scanty cytoplasm. There are deposits of connective
tissue mucin between the cells. Mitotic figures are not apparent in these
sections.
DIAGNOSIS: SCAR AND RESIDUAL SPINDLE-CELL NEOPLASM
Note: Immunostains for a panel of mesenchymal markers are being done to
better define the lesion. The neoplasm extends to the lateral margins of the
excision.
Answer Hello Jerry:
Neurofibroma and neuroma are benign tumors of the peripheral nerves.
These are composed of spindle shaped cells. The cell of origin or their cause of occurrence is not known.
Neurofibromas require complete excision. Even if few cells are left behind the lesion can recur. It does not spread to other locations. However if there is a genetic predisposition multiple neurofibromas can arise in different locations.
On the biopsy they are not able to characterize the specif tumor as there are many times of tumors of nerve origin.
However, by the report this is most likely a benign lesion.
