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Pathology/How to understand pathology report for bone marrow

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How do I read these hieroglyphics? I have been chasing myself in an effort to google all this. :-) " T Lymphocytes represent approximately 3/4 of the events....predominate t lymphoid polulation expresses TCR A/B with rare events being TCR G/D positive... b lymphocytes represent approx 1/4 of events...kappa and lmabda light chain is polyculonal by light chain analysis.

        R1    R2    R3    R4
CD 10     5%    6%   38%  10 %
CD 19     23%    3%   0%  10%
CD 5      66%    8%    0%   0%
cd3       68%    7%   0%    0%
CD7       71%    6%   0%   2%
CD56      7%     2%   1%   2%
CD3       67%    11%  0%    1%
CD20      21%    4%   0%   2%
CD4       35%    33%  0%   3%
cd8       32%    4%   0%   0%
FMC7      11%    0%   0%   0%
CD19      20%    4%   0%   7%
CD23      16%    2%   0%   0%
KAPPA     13%    1%   0%   2%
CD19      20%    1%   0%   26%
LAMBDA     7%    2%   0%   3%
CD22      20%    1%   0%   0%
CD19      24%    5%   0%   7%
HLADR     37%    85%  4%   96%
CD13       1%    97%  95%  80%
CD33       1%    99%  99%  83%
CD34       0%     0%  0%   13%
CD117      0%     2%  2%   11%
TCR A/B    65%    10%  0%   0%
CD3        69%    10%  0%   0%
TCR G/D    4%      0%  0%    0%
CD16/56    9%     30%   33%   65%
CD57       1%     0%    0%    1%

Non-specific, non-diagnostic immunophenotype with 1. T lymphoid predominance , and 2 NO immunophenotypic evidence of signigiant myeloid immaturity.

Answer
Hello E

The flow report gives information about the type  and percentage of lymphocytes present in the sample analyzed. There are two types of lymphocytes - B and T the various CD markers with numbers attached to them eg, CD10, CD19. These all are expressed by the B and T cells at various stages of maturation.

Your report indicates that majority of of the lymphocytes are mature and predominantly T lymphocytes. (more percentage of CF3 and Cd4 cells)versus CD19 and CD20 whihc are markers for B lymphocytes

There are polyclonal kappa and lambda light chains. Again good news as monoclonal chains would indicate presence of malignancy.

Overall the report does not indicate any obvious abnormality.

Pathology

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Neha Dahiya MD

Expertise

Help patients understand the medical terminology of their lab results and / or tissue biopsy reports.

Experience

I am a pathologist and director of clinical laboratory services. I have been a practicing pathologist for last 9 years in a 350 bed multi specialty hospital laboratory in India.

Organizations
Indian association of pathologists and microbiologists.
International Academy of Cytology
International association of Pathologists - Indian division
Indian association of Cytology

Education/Credentials
MD (pathology) MBA

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