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Pediatrics/High Fever and Crying after Pneumococcal+DTP Injection+OPV



My son is 4 months old. He had got one shot of Pneumococcal injection and one shot of DTP+Hib vaccine + OPV yesterday.

He had previously got two shots of Pneumococcal injection and 2 shots of IPV+DTP+Hib vaccine(Pentaxim) and he had no fever nor was there any discomfort(Severe Crying) after the injection. However, this was not the case after the recent Pneumococcal and DTP+Hib injection+opv.The following were the differences in terms of vaccination:

1) The brand initially used  was Prevenar 13 but the brand of Pneumococcal used yesterday was Synflorix.

2) Initially, Pentaxim was administered but yesterday, it was a combination of DTP vaccine+ OPV.

My question is , should I stick to Pentaxim and Prevenar 13 for future injections or is it normal to have high fever and discomfort after a DTP injection, eventhough this did not happen the firsttime around. I look forward to your response. Thanks.

Best Regards,

ANSWER: Hi Vimal,

The DTP vaccine is known to cause pain and fever. Pentaxim has DTaP (acellular pertussis component), which causes much less pain and fever than usual DPT. Otherwise bot DTP and DTaP are equally good as far as effectiveness is concerned. Whether you go fr DTP ot DTaP in future is YOUR choice.

Regarding pneumococcal vaccine, the brand should not have been changed. Prevenar 13 and Synflorix are different vaccines and same brand should ideally be continued. Please take Prevenar 13 only in future

Best wishes,
Dr. Puneet Kumar,
Kumar Child Clinic, Dwarka,
New Delhi, India


---------- FOLLOW-UP ----------


Thanks for your prompt and precise response.

I have one more query regarding vaccinations.

My son had Pentaxim vaccination(DtaP-IPV+Hib)in the 9th and 13th week respectively. In the 17th week, he had a DTP vaccinations and OPV. When and how many more doses of IPV injection should be taken ?

Hi Vimal,

He would need one injection (3rd dose) now followed by booster (along with DTP/ DTaP and Hib booster at 16-18 months of age. In addition, OPV should be taken at 6 month, 9 month and 4.5-5 years of age and also at all Pulse Polio rounds till 5 years of age.

You can see the latest immunization schedule as recommended by Indian Academy of Pediatrics at:

Best wishes,
Dr. Puneet Kumar,
Kumar Child Clinic, Dwarka,
New Delhi, India



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Dr. Puneet Kumar


I would be happy to answer general queries on prevention and treatment of ailments in newborn, infant, toddler, child or an adolescent. Needless to say, it will not be possible to answer any query that requires diagnosing, since it is not possible to examine a child online.


I have worked in various capacities (medical officer, resident, senior resident, consultant) in public as well as private sector in Pediatrics and Neonatology. Today, I have over 17 years of experience in the field.

Currently, I am running my own clinic (Kumar Child Clinic) in Dwarka, New Delhi and am attached to Lifeline Hospital, Dwarka as consultant pediatrics and neonatology. I am also developing my clinic website into a comprehensive child health/ parenting website (

(a) Chapter "National Immunization Schedule" in Frontiers of Social Pediatrics, Jaypee Publishers: 2nd edition, 2016. (b) Article, "All about Pertussis vaccines" in special issue of Indian Journal of Practical Pediatrics, July-Sept 2015 (c) Three chapters (DTP vaccines, Pneumococcal vaccines and Poliovirus vaccines) in "Textbook of Pediatrics for Post-graduates" First edition: 2015. (c) Chapter: "Alternative delivery methods of vaccines" in IAP textbook of Vaccines, First edition, 2014 (published by IAP/ Jaypee Brothers) (d) Special Article: "50 years of Immunization in India: Progress and Future" in January 2013 issue of Indian Pediatrics (e) Four chapters in "FAQ: Book on Vaccines and Immunization Practices" First edition, 2011 AND 2nd edition, 2015 published by Jaypee Brothers. (f) Three articles in special issue of Journal of Pediatric Sciences on “Controversies and Challenges in Pediatric Vaccination Today" in Sept, 2010. Co-edited the series also. (f) Regular column, “How do I treat” in Pediascene ( (g) Review article, “Role of Anti-Poliovirus Agents in Polio eradication and beyond” in Polio Pulse, April, 2008. (h) Chapter on “Acute Infectious Diarrhea” in Textbook of Infectious Diseases in Children. (An IAP Publication), 2007. 2nd edition in 2011. (i) Book-Review (IAP Pediatric Drug Formulary, 2004) in Pediascene, March 2005 ( ) (j) Case-report on Osteopetrosis. Jharkhand Journal of Pediatrics, Dec-2002.

After MBBS, I have done DNB residency in Pediatrics.

Awards and Honors
Winner of IAP practising pediatrician's quiz in 2001.

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