You are here:

Pharmaceuticals/Permanency of tolerance?


I have struggled with insomnia for many years. When my doctor suggested Ambien some time back, my first question was if it would cause dependence on the drug.  While it remains effective and I have no tolerance issues with it, I have found that I became dependent on it. After taking it for a few years, I came to a point where I could no longer sleep at all without it (making my insomnia issue worse than it was before).

I went back to my doctor and she recommended trying Temazepam. It is not very effective, but it does allow me to sleep without needing Ambien. However, I quickly developed a tolerance and it no longer has any effect.

I would like to try toggling between the two treatments, so that I can switch between taking Ambien and Temazapam for a few months at a time, so that hopefully I won’t be dependent on Ambien and won’t have a tolerance to Temazapam.  My doctor said it was worth a try, but didn’t seem to be able to answer my concerns about it.

If someone develops a tolerance to Temazepam, how long would it take to subside? Or would it be fairly permanent? With Ambien, how long would someone need to stay away from it so they could sleep without using it (or as well as an untreated insomniac relatively could)?



Dear Chuck,
I am not a medical practitioner but on basis of general information, I will respond to you.
Insomnia can be for different reason. when you took medicine such as CNS depressants then you are actually giving a habit of drug to nervous system.

Your body need medicine to get you sleep and when you leave it then it will take sometime or long time to get out of that need.

Inspite of medicine I will ask you to do meditation and relaxation to get sleep. Wash your feet with water before going to bed. Do not involve your brain in any work which bothers you in night, at least 1 hour before going bed.

In bed think of your positive and happy moments of life.
This will helps you to get sleep.  


All Answers

Answers by Expert:

Ask Experts


Himanshu Gupta, Ph.D


I can answer questions related to pharmaceutical formulation, research and publications.


Experienced Formulation Scientist with doctoral degree in Pharmaceutical Sciences. Significantly contributed for advancement of projects at various stages of drug product development cycle from conceptualization to proof-of-concept studies in animals that resulted in invention disclosures. Efficient and diligent team worker with proven track record of being problem solving and innovative. Areas of expertise include: • Formulation and product development for ocular, transdermal and skin care area. • Preformulation and related analytical techniques. • In vitro drug release, skin/corneal permeation studies, irritation/toxicity studies • In vivo: ocular retention (rabbits), intravitreal injection in rats, blood collection through heart puncture, tumor induction in mice, oral/ocular dosing in rats. • Radiolabeling of drug molecule with Tc99m and taking images using gamma camera. • SOP and report writing as per GLP compliance • Biomaterial i.e. absorbent, contact lens and Intraocular lens • Teaching experience in pharmaceutics and hospital pharmacy • Serving as board member in working of non-profit organization and scientific journals. Specialties: Formulation and product development (ocular, transdermal, skin care), Polymeric nanoparticles, in situ gel, pHEMA gel and emulsion based formulation development, excipient interaction and stability study, In vitro and in vivo evaluation of drug products, ocular/skin irritation studies, radiolabeling of small drug molecules, preclinical drug evaluation in rabbits and rats, Franz diffusion cell for skin/corneal permeation studies, SOP and report writing, documentation for regulatory submissions, analytical techniques such as HPLC, UV-Vis, DSC , viscometer, osmometer, DLS, SEM, ERG (Electro retinography), IR camera. Hands on instrument experience for formulation development i.e. high pressure homogenizer, lyophilizer, ultra sonicator, ultra centrifuge, autoclave, gamma sterilization, cold compression etc.

Organization of Pharmaceutical Unity with BioAllied Sciences (OPUBS) University of Toledo Auburn University University of Colorado Recent Patent DDF Journal of Pharmacy and Bioallied Sciences

Publications & Citations Citations record (>300 citations) 1. Himanshu Gupta, Sanyog Jain, Rashi Mathur, A.K. Mishra, Pushpa Mishra, T.Velpandian, Sustained ocular drug delivery from a temperature and pH triggered in-situ gel system, Drug Delivery 14(8) 2007, 507-515. 2. H. Gupta, R.M. Singh, G.N.Singh, A. Sharma, D. Kaushik, pH induced in-situ gel for periodontal anesthesia, Indian Journal of Pharmaceutical Sciences 70(6) 2008, 776-778. 3. Himanshu Gupta, M. Aqil, R.K. Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mittal, Sanyog Jain. Development and characterization of Tc-99m timolol maleate for evaluating efficacy of in situ ocular drug delivery system, AAPS Pharm. Sci.10(2) 2009, 540-546. 4. Himanshu Gupta Dheeraj Singh, Preet Tyagi, R.K. Diwan, R.K. Khandal, Vinod Paul, Ramesh Aggarwal, Amita Malik, Performace evaluation of market available diapers: Materials and Properties, Indian Journal of Pediatrics 76(8) 2009, 859-60. 5. Himanshu Gupta, Dinesh Bhandari, Aarti Sharma, Recent Trends in Oral Drug Delivery: A Review, Recent Patents on Drug Delivery & Formulation 3 (2) 2009, 162-173. 6. Himanshu Gupta, Aarti Sharma, Tripti Dixit, Intraocular lens and biocompatibility- A Review, Recent Patents on Biomedical Engeniering 2 (2), 2009, 148-156. 7. Himanshu Gupta, Aarti Sharma, Ion activated bioadhesive in situ gel of clindamycin for vaginal application, International Journal of Drug Delivery 1 (1) 2009, 32-40. 8. Himanshu Gupta, M. Aqil, R.K. Khar, Asgar Ali, A. Sharma, Prakash Chander, Development and Validation of Stability Indicating RP-UPLC method for the Quantitative analysis of Sparfloxacin. Journal of Chromatographic Science 48 (1) 2010, 1-6. 9. Himanshu Gupta, Aqil Malik, R.K. Khar, Asgar Ali, Prakash Chander, A Single RP-UPLC method for quantification of Levofloxacin in aqueous humour and pharmaceutical dosage forms, Journal of chromatographic Science 48, 2010: 484-490. More on link..

Diploma in Pharmacy, Bachelor in Pharmacy, Masters in Pharmacy (Pharmaceutics), Post Graduate Diploma in International Business (PGDIB), Certificate in IPR, PhD (Pharmaceutics), Post Doctorate (Pharmaceutics)

Awards and Honors
- Hamdard Appreciation Award 2011 - Awarded with “Dr. P. D. Sethi Annual Award 2010” - Received International travel grant from DST, Ministry of Science and Technology (Govt. of India) for 37th CRS, USA. - Invited to Moderate “Nanotechnology I” session in 37th Annual Meeting and Exposition of the Control Release Society, Portland, Oregon, USA 10-14 July 2010 - Awarded “Budding Nanotechnologist Award” (Young Scientist Award) in DST (Ministry of Science and Technology, Govt. of India) sponsored 2nd Summer School on Nanotechnology in Advanced Drug Delivery, NIPER, Chandigarh, 2009. - Received SRF fellowship of Central Council of Scientific and Industrial Research (CSIR), Govt. Of India, New Delhi, India. - Awarded SRF fellowship of Indian Council of Medical Research (ICMR), Govt. of India, India. - Conference Grant from Society of Nuclear Medicine (India) - Organized planary lectures and symposium with scientific committee in 60th IPC. - Conference Grant from IOMC

Past/Present Clients
Member Organization of Pharmaceutical Unity with BioAllied Sciences (OPUBS) Public Company; 11-50 employees; Nonprofit Organization Management industry January 2010 – Present (2 years 6 months) Organization of Pharmaceutical Unity with BioAllied Sciences (OPUBS) is an educational society registered under “The Societies Registration Act, 1860” with Govt. of India. We assist scientific communities, students and researchers. We help them with every aspect of education, research and publication to grow and prosper in their respective field. I work for all projects and their working. Post Doc- VRA University of Colorado-Anschutz Medical Campus, Denver, USA Educational Institution; 51-200 employees; Higher Education industry June 2011 – May 2012 (1 year) Aurora, CO, USA Research on novel drug delivery systems Senior Research Fellow Council of Scientific and Industrial Research Government Agency; 10,001+ employees; Research industry April 2009 – June 2011 (2 years 3 months) New Delhi Area, India Working on my PhD project PhD Scholar Faculty of Pharmacy, Jamia Hamdard, New Delhi November 2007 – June 2011 (3 years 8 months) Pursuing my PhD (Pharmaceutics). I am working on novel drug delivery systems i.e. ocular drug delivery. Research Associate Shriram Institute for Industrial research September 2007 – January 2008 (5 months) Biomaterials and nanotechnology Lecturer BIT, UP Technical University May 2006 – September 2007 (1 year 5 months) Teaching B.Pharm students

©2017 All rights reserved.