AboutDr Alan Galbraith Expertise I can answer most questions on drugs, both medical and "recreational". Answers can be given in either technical or layperson terminology. My main areas of interest are psychiatric, gastrointestinal and cardiovascular drugs.
Experience I have been a university lecturer/head of department for almost thirty years, but am now retired. My research interests were alcohol, smoking and cardiovascular disease.
Organizations Institute of Biology, London.
Publications Principal author of "Fundamentals of Pharmacology" 4th Edition published in November 2003 by Pearson Education, Australia.
Expert: Dr Alan Galbraith Date: 4/14/2008 Subject: genetic polymorphism
Question which other isozymes of cytochrome P450 exhibit genetic polymorphism? for each case give an example of a drug that would normally be metabolised by each isozyme and the clinical implications of genetic polymorphism. 5 marks
Answer Dear Mahria
1. Main ones are CYP2D6 and CYP2C9. Secondary one is CYP2C19
2. CYP2D6 - over 100 drugs eg SSRIs
CYP2C9 - benzodiazepines; ibuprofen
CYP2C19 - tamoxifen
3. Excess of these isoenzymes can produce non-responsiveness or conversely lack of can produce an exaggerated or even toxic response.
No 3 can be amplified on and I am sure you can do this for yourself.
