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About Dr. Ravindra Bhaskar Ghooi
Expertise
I can provide information on drugs and medicines, their actions, uses, interactions and adverse effects. To avoid confusion, generic names of medicines may please be provided. I am a pharmacologist, having worked on animal and human pharmacology, and presently I am the Dean of Bilcare Research Academy, where we teach courses on clinical research. We dont work on saturdays and sundays, hence questions reachng me on these days will be replied on Monday, please bear with me.

You are here: Experts > Health/Fitness > Pharmacology > Pharmacy > A combination of Ibuprofen and zaltoprofen

Topic: Pharmacy

Expert: Dr. Ravindra Bhaskar Ghooi
Date: 5/6/2008
Subject: A combination of Ibuprofen and zaltoprofen

Question
Hello Dr. Ravi Ghooi
I work with a pharmaceutical API mfg company.I wanted to enquire whether a drug combination of Zaltoprofen and Ibuprofen is possible. Zaltoprofen being relatively a newer molecule how conducive is it as a combination?

Kindly revert at your earliest.

Your truly
Aarti Vedamoorthy

Answer
Hi Aarti,
Zaltoprofen has a mechanism which includes inhibition of bradykinin mediated effects. It is believed to be a selective COX II antagonist, unlike ibuprofen which is a non selective one. So why would you like to mix these two compounds? The mixture will be non selective. Additionally will the DCGI or FDA allow it? am not sure whether you want a reply from the regulatory point of view or pharmacological point of view, but I guess either way it would not be a good idea to mix the two. So far my opinion is not in favour, but if you have a specific reason to mix them I am willing to discuss the advantages. Please write to rghooi@gmail.com so that we may discuss the issue.
Ravi Ghooi

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