AboutDr Alan Galbraith Expertise I can answer most questions on most drugs. Answers can be given in either technical or layperson terminology. My main areas of interest are psychiatric, gastrointestinal and cardiovascular drugs.
Experience I have been a university lecturer/head of department for almost thirty years, but am now retired. My research interests were alcohol, smoking and cardiovascular disease.
Organizations Institute of Biology, London.
Publications Author of "Fundamentals of Pharmacology" 5th Edition published in November 2007 by Pearson Education, Australia.
Question I am hypertensive currently taking atenolol 100 amlodepine 10 mg losartan 100 and hctz 12.5 mg. Due to elevation of BP from 125/80 to 140/90 continuously, my dr deleted HCT 12.5 replaced with Indapamide 1.5 SR. I told him if HCT can be 25, then various combination like enalpril HT ( Enalpril 10 + HCT25)available which is a convenient. My 2 queries. Is it true that HCT more than 12.5 harmful ? Secondly if I switch over to enalapril ( previously I used to take it but discontinued becuase dr said there are better drugs available) what dose of enalpril I am to take roughly and whether I am likely to loose the benefits of losartan over enalpril. This is because of economy aspect and that I have no cough problem Thanx
Answer Dear Ashish
I see no reason why you cannot try 20mg enalapril instead of the 100mg losartan if your doctor agrees. With the HCT it could be different as increasing the dose to 25 mg often does not cause any significant change in BP but will increase urinary frequency whereas the indapamide may not affect this all that much. Apart from that you culd give it a try. The option often Enalapril with HCT would be my first option but not at the 10mg dose as previoously said.
