Expert: Dr. Ravindra Bhaskar Ghooi - 8/31/2009

Question
sir please tell me a latest antifungal durg that can be administered topically & systemically both ,and its availability in india,and the name of manufacturer company.

Answer
Hi Nitin,
Antifungal drugs are classified as follows:

Imidazoles
Miconazole – miconazole nitrate
Ketoconazole
Clotrimazole – marketed as Lotrimin or Lotrimin AF (and Canesten in the UK)
Econazole
Bifonazole
Butoconazole
Fenticonazole
Isoconazole
Oxiconazole
Sertaconazole – marketed as Ertaczo in North America
Sulconazole
Tioconazole
The triazoles are newer, less toxic and more effective:

Triazoles
Fluconazole
Itraconazole
Isavuconazole
Ravuconazole
Posaconazole
Voriconazole
Terconazole

Thiazoles
Abafungin

Allylamines
Allylamines inhibit squalene epoxidase, another enzyme required for ergosterol synthesis:

Terbinafine – marketed as "Lamisil" in North America, Australia, the UK, Germany and the Netherlands
Amorolfine
Naftifine – marketed as "Naftin" in North America
Butenafine – marketed as Lotrimin Ultra

Echinocandins
Echinocandins inhibit the synthesis of glucan in the cell wall, probably via the enzyme 1,3-β glucan synthase:

Anidulafungin
Caspofungin
Micafungin

Others
Benzoic acid – has antifugal properties but must be combined with a keratolytic agent such as in Whitfield's Ointment[1]
Ciclopirox – (ciclopirox olamine), most useful against Tinea versicolour
Tolnaftate – marketed as Tinactin, Desenex, Aftate, or other names
Undecylenic acid – an unsaturated fatty acid derived from natural castor oil; fungistatic as well as anti-bacterial and anti-viral
Flucytosine or 5-fluorocytosine – an antimetabolite
Griseofulvin – binds to polymerized microtubules and inhibits fungal mitosis
Haloprogin – discontinued due to the emergence of more modern antifungals with fewer side effects
Sodium bicarbonate (NaHCO3)

Very fw of these compounds are avalable in India. What are available in India are given on the site http://www.medlineindia.com/antibiotic/antibiotics.htm
Here you will find all anti fungals available in ndia with their costs and manufacturer details. Depneding upon what indication you are searching for you should choose the agent, voriconalzole is one of the latest drugs available as tablet and Injection from Maxter. If you need any mre information please revert to me.
Ravi Ghooi