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Pharmacy/release pattern


i am vyas maharshi studying in manavar college of pharmacy at rajkot.My project on sustained release matrix table,but i dont know what is different between sustained and controlled release?several time i am asking to my respected guide,but i could not get proper answers.i hope you give it.Thanking you.

Sustained released means that the drug will be released under first order kinetics. Therefore if a drug starts out at 100 mg and releases at a rate of 10% per unit time.

100mg --> 90mg --> 81mg -->72.9 mg ..

Controlled release means that the drug will be released under zero order kinetics so 10mg per unit time

100mg -->90mg -->80 mg --> 70 mg ..etc
Hope this helps, Mary


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Mary E Scott, RPh, CGP


I am a certified geriatric pharmacist with over 23 years experience as a long-term care consultant to nursing homes. I also do community-based consulting on an individual basis. My facility-based monthly newsletter on pharmacy topics is read by nurses in over 200 long-term care facilities in 5 states.


I received a BS in Pharmacy in 1980 with post-graduate work in public health. I have had a Consultant Pharmacist license since 1984.

American Society of Consultant Pharmacists
.I received certification in geriatric pharmacy in 1998.

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