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Pharmacy/Ranitidine, Pantoprazole


Dear Sir,

I have to take anti depressants such as Imipramine probably forever and a number of other anti psychotic drugs so in the long term I don't want my stomach damaged. Seldom happens my stomach reacts to Imipramine like when it is empty. I don't know if AluminiumMg is recommended to take daily, however I know these two other drugs Ranitidine and Pantoprazole (Enteric coated tablet). How do you recommend to take any of these two drugs ?
☆ COULD I take Ranitidine and Pantoprazole "occasionally" ? Does Pantoprazole work in the small intestine (?) as my worry is the stomach first.
Do I have to take them 1 hour before Imipramine ? Do you have any further advice ?

Thanks in advance,

Sincerely yours,



Whilst generally there is no problem taking either Ranitidine or Pantoprazole on an "as required" basis, I'm not altogether sure they will help with your problems.

Drugs like Imipramine have what are called anti-cholinergic side-effects. These effects can include blurred vision, dry mouth and some gastro-intestinal problems. Imipramine can prevent the production of saliva (hence the dry mouth) and the release of stomach acid which is needed to aid digestion of food. This can result in feeling usually described as "indigestion", which people usually treat with antacids or acid suppressants such as Ranitidine and Pantoprazole. So potentially these drugs may not really help your problems.

If you find Ranitidine or Pantoprazole does help, then it's fine to continue. However if you find no real benefit, then I would not persist.

There is no reason why either drug cannot be taken at the same time as Imipramine.

I hope this helps.


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Nigel Simmons


I am happy to answer general questions on medicines and hospital care. If possible, please use approved / chemical names rather than brands which are not internationally recognised. Like all health professionals I am bound by a duty of care which prevents me giving detailed information about medication or treatment of people other than the questioner. I will endeavour to help wherever possible or point towards more appropriate advice. If however your question crosses too far into patient confidentiality, I hope you will understand why I cannot answer your question. Consider.. would you want me to discuss your care with a friend or relative without your knowledge?


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