In your opinion, do you think the anti hypertensive, Aldactone, (spirinolactone) is safe for a breast cancer patient to take? I have read conflicting views of this. My family doctor wants to put me on 25mg aldactone daily for my high blood pressure but I had stage 3 breast cancer in 2003 and an reluctant to take a drug that may interfere with my hormones as my cancer was estrogen/prosgesterone positive. Thank you for your time and consideration.
Spironolactone is a specific aldosterone antagonist, it is also an antagonist of the androgen receptors. It therefore would have some effects on the estrogen progesterone system too, and would affect EP Positive breast cancers, either positively or negatively. The drug stimulates progesterone receptors in doses about 10 times more than those required to antagonize androgen receptors.
Since your tissue was ER+ and PR+, the growth was promoted by estrogen and progesterone. Spironolactone is a stimulant of progesterone receptor hence we need to be very careful with it.
We really need to look up what other people have found with spironolactone is such cases.
Between 1965 and 2015 there are 39 reports of the association of spironolactone and breast cancer. No study reports the use of the drug in patients with a history of breast cancer. Two Studies one from Denmark and one from UK are really important since they report the result with 2.3 and 1.2 million women respectively. Neither found any association of spironolactone with breast cancer.
Cautiously I would say that there is adequate reason to believe that spironolactone is not a risk in you. It does stimulate the progesterone receptor but at doses which are 10 times higher than those used clinically. However I am sure you physician will have an opinion and your health is the responsibility of that physician. Thus while giving this opinion, I would yield to the decision by your primary physician whether to use the drug or not.
All the best