QUESTION: Respected Dr Ravi sir,
I had sought guidance recently as regards Lasilactone 50 and your responses were reassuring.
However, with the Lasilactone 50 my bp has been under control like 135/85 and 130/80. But its side effect like urination frequence after taking it in morning is pronounce and uoto 3 to 4 hours I feel body moisturised and hydrated. Secondly besides lasilactone 50 I am taking Atenolol 100 Amlodipine 10 mg Nd losartan 100 mg . My worry is abt side effect profile like possibility of elevation in creatinine hairfall malreast enhancement. What to do ? My family physician says I have 2 options ; 1. I may discontinue lasilactone and start Dytor plus since it has less incidence of kidney damage. 2. I may discontinue lasilactone and take Amlopress At and Losar H morning at 8 am. Around 6 evening I may repeat Amlopress AT and Losar H. Pl guide me. I am seeking guidance as I am confused. I am not scared of frequent urination agter taking lasilactone but I am scared of side effect profile like creatinine elevation kidney damage etc since in my family and my citcle I am a witness to lot of members suffering kidney problems. Hence I am bothering you. Re
Personally I dont think that lasilactone puts you at a greater risk. I am not saying that the reports of side effects are wrong but in very cases is it proved that the side effects were caused by the drug under question. About 50% of aide effects have no relation with the drug in question, so I would request you to take the drug for a few days and then let us think if a change is required.
All the best.
---------- FOLLOW-UP ----------
Many thanx for response with reassurance. I have been taking lasilactone 50 since last 22 days. My PCP says tha Torsemide causes lesser kidney damage. Is it true ? In that event, should I give Dytor plus a try ?
I have been searching information about these drugs unfortunately a combination of furosemide and spironolactone is not available anywhere hence getting data on direct comparison of this formulation with torsemide is difficult to fine. However going through data on individual drugs suggests that torsemide does have very little kidney toxicity, where as renal effects are listed for spironolactone. However the exact percentage of patients who went into kidney failure following the use of this drug is not known. It is therefore very difficult to predict the safety. To be very honest I am unable to say if one is better than the other. On one hand you have the efficacy of combination which is better and on the other you have a higher toxicity. So this is a decision one must take on ones own. But I personally am using spironolactone for the last five years and would not shift despite available evidence.
All the best