Expert: Dr. Ravindra Bhaskar Ghooi - 5/6/2007

Question
Hi, I am curious about the interactions between Diphenhydramine and LSD, if there are any? I am wondering because Fluoxetine and other SSRI decrease the effects of LSD; Diphenhydramine has antidepressant like properties and has similarities to Fluoxetine.  So does Diphenhydramine decrease the effect of LSD or have any interactions at all?

Answer
Hi Alex,
This is a very difficult question to answer. You would agree that since LSD is not legal, there are n scientific trials in which such nteractions have been studied. What ever reports are available involve illegal use of the drug, and hence these have not been scientifically validated or verified. Many such reports are available on the net, and you may access them through google. I would not like to comment on any of them since they are not peer reviewed nor scientifically acceptable.
Ravi Ghooi